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Efficacy of the TMP...
Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial
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- Gunst, Jesper D. (författare)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
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- Staerke, Nina B. (författare)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
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- Pahus, Marie H. (författare)
- Deptarment of Clinical Medicine, Aarhus University, Aarhus, Denmark
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- Kristensen, Lena H. (författare)
- Deptarment of Medicine, Viborg Regional Hospital, Denmark
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- Bodilsen, Jacob (författare)
- Deptarment of Infectious Diseases, Aalborg University Hospital, Denmark
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- Lohse, Nicolai (författare)
- Deptarment of Emergency Medicine, Copenhagen University Hospital, Hillerød, Denmark; Deptarment of Clinical Medicine, Copenhagen University, Copenhagen, Denmark
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- Dalgaard, Lars S. (författare)
- Deptarment of Medicine, Regional Hospital West Jutland, Herning, Denmark
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- Brønnum, Dorthe (författare)
- Centre for Clinical Research, North Denmark Regional Hospital, Hjoerring, Denmark
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- Fröbert, Ole, 1964- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Dept. of Cardiology
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- Hønge, Bo (författare)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Internal Medicine, Randers Regional Hospital, Randers, Denmark
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- Johansen, Isik S. (författare)
- Research Unit for Infectious Diseases, Odense University Hospital, University of Southern Denmark, Denmark
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- Monrad, Ida (författare)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
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- Erikstrup, Christian (författare)
- Deptarment of Clinical Medicine, Aarhus University, Aarhus, Denmark; Deptarment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark
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- Rosendal, Regitze (författare)
- Deptarment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark
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- Vilstrup, Emil (författare)
- Deptarment of Medicine, Viborg Regional Hospital, Denmark
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- Mariager, Theis (författare)
- Deptarment of Infectious Diseases, Aalborg University Hospital, Denmark
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- Bove, Dorthe G. (författare)
- Deptarment of Emergency Medicine, Copenhagen University Hospital, Hillerød, Denmark
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- Offersen, Rasmus (författare)
- Deptarment of Medicine, Regional Hospital West Jutland, Herning, Denmark
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- Shakar, Shakil (författare)
- Deptarment of Internal Medicine, North Denmark Regional Hospital, Denmark; Deptarment of Emergency Medicine, North Denmark Regional Hospital, Denmark
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- Cajander, Sara, 1980- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Deptarment of Infectious Diseases
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- Jørgensen, Nis P. (författare)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Internal Medicine, Randers Regional Hospital, Randers, Denmark
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- Sritharan, Sajitha S. (författare)
- Deptarment of Medicine, Viborg Regional Hospital, Denmark
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- Breining, Peter (författare)
- Deptarment of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark
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- Jespersen, Søren (författare)
- Deptarment of Emergency Medicine, Copenhagen University Hospital, Hillerød, Denmark
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- Mortensen, Klaus L. (författare)
- Deptarment of Medicine, Regional Hospital West Jutland, Herning, Denmark
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- Jensen, Mads L. (författare)
- Deptarment of Medicine, Viborg Regional Hospital, Denmark
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- Kolte, Lilian (författare)
- Deptarment of Lung and Infectious Diseases, Copenhagen University Hospital, Hillerød, Denmark
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- Frattari, Giacomo S. (författare)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
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- Larsen, Carsten S. (författare)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
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- Storgaard, Merete (författare)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
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- Nielsen, Lars P. (författare)
- Deptarment of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Biomedicine, Aarhus University, Aarhus, Denmark
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- Tolstrup, Martin (författare)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Clinical Medicine, Aarhus University, Aarhus, Denmark
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- Sædder, Eva A. (författare)
- Deptarment of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Biomedicine, Aarhus University, Aarhus, Denmark
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- Østergaard, Lars J. (författare)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Clinical Medicine, Aarhus University, Aarhus, Denmark
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- Ngo, Hien T. T. (författare)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
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- Jensen, Morten H. (författare)
- Deptarment of Health Science and Technology, Aalborg University, Aalborg, Denmark; Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark
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- Højen, Jesper F. (författare)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
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- Kjolby, Mads (författare)
- Deptarment of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark; DANDRITE, Deptarment of Biomedicine, Aarhus University, Aarhus Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital, Denmark; University of Dundee, Scotland, United Kingdom
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- Søgaard, Ole S. (författare)
- Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Clinical Medicine, Aarhus University, Aarhus, Denmark
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: eClinicalMedicine. - : Elsevier. - 2589-5370. ; 35
- Relaterad länk:
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https://doi.org/10.1...
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http://www.thelancet...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: The trans-membrane protease serine 2 (TMPRSS2) is essential for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry and infection. Efficacy and safety of TMPRSS2 inhibitors in patients with coronavirus disease 2019 (Covid-19) have not been evaluated in randomized trials.Methods: We conducted an investigator-initiated, double-blind, randomized, placebo-controlled multicenter trial in patients hospitalized with confirmed SARS-CoV-2 infection from April 4, to December 31, 2020. Within 48 h of admission, participants were randomly assigned in a 2:1 ratio to receive the TMPRSS2 inhibitor camostat mesilate 200 mg three times daily for 5 days or placebo. The primary outcome was time to discharge or clinical improvement measured as ≥2 points improvement on a 7-point ordinal scale. Other outcomes included 30-day mortality, safety and change in oropharyngeal viral load. ClinicalTrials.gov Identifier: NCT04321096. EudraCT Number: 2020-001,200-42.Findings: 137 patients were assigned to receive camostat mesilate and 68 to placebo. Median time to clinical improvement was 5 days (interquartile range [IQR], 3 to 7) in the camostat group and 5 days (IQR, 2 to 10) in the placebo group (P = 0·31). The hazard ratio for 30-day mortality in the camostat compared with the placebo group was 0·82 (95% confidence interval [CI], 0·24 to 2·79; P = 0·75). The frequency of adverse events was similar in the two groups. Median change in viral load from baseline to day 5 in the camostat group was -0·22 log10 copies/mL (p <0·05) and -0·82 log10 in the placebo group (P <0·05).Interpretation: Under this protocol, camostat mesilate treatment was not associated with increased adverse events during hospitalization for Covid-19 and did not affect time to clinical improvement, progression to ICU admission or mortality.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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Gunst, Jesper D.
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Staerke, Nina B.
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Pahus, Marie H.
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Kristensen, Lena ...
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Bodilsen, Jacob
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Lohse, Nicolai
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visa fler...
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Dalgaard, Lars S ...
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Brønnum, Dorthe
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Fröbert, Ole, 19 ...
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Hønge, Bo
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Johansen, Isik S ...
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Monrad, Ida
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Erikstrup, Chris ...
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Rosendal, Regitz ...
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Vilstrup, Emil
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Mariager, Theis
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Bove, Dorthe G.
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Offersen, Rasmus
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Shakar, Shakil
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Cajander, Sara, ...
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Jørgensen, Nis P ...
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Sritharan, Sajit ...
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Breining, Peter
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Jespersen, Søren
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Mortensen, Klaus ...
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Jensen, Mads L.
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Kolte, Lilian
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Frattari, Giacom ...
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Larsen, Carsten ...
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Storgaard, Meret ...
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Nielsen, Lars P.
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Tolstrup, Martin
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Sædder, Eva A.
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Østergaard, Lars ...
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Ngo, Hien T. T.
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Jensen, Morten H ...
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Højen, Jesper F.
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Kjolby, Mads
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Søgaard, Ole S.
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Örebro universitet