Sökning: WFRF:(Tarnoki David L)
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Heritability of Car...
Heritability of Cardiothoracic Ratio and Aortic Arch Calcification in Twins
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- Jokkel, Zsofia (författare)
- Medical Imaging Centre, Semmelweis University, Budapest, Hungary
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- Forgo, Bianka, 1992- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Radiology
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- Hani-Gaius Ghattas, Christopher (författare)
- Medical Imaging Centre, Semmelweis University, Budapest, Hungary
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- Piroska, Marton (författare)
- Medical Imaging Centre, Semmelweis University, Budapest, Hungary
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- Szabó, Helga (författare)
- Medical Imaging Centre, Semmelweis University, Budapest, Hungary
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- Tarnoki, David L. (författare)
- Medical Imaging Centre, Semmelweis University, Budapest, Hungary
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- Tarnoki, Adam D. (författare)
- Medical Imaging Centre, Semmelweis University, Budapest, Hungary
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- Lee, Soo-Ji (författare)
- Genome and Health Big Data Laboratory, Department of Public Health, Graduate School of Public Health, Seoul National University, 1 Gwanak-ro Gwanak-gu, Seoul, Korea, Institute of Health and Environment, Seoul National University, 1 Gwanak-ro Gwanak-gu, Seoul, Korea
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- Sung, Joohon (författare)
- Genome and Health Big Data Laboratory, Department of Public Health, Graduate School of Public Health, Seoul National University, 1 Gwanak-ro Gwanak-gu, Seoul, Korea, Institute of Health and Environment, Seoul National University, 1 Gwanak-ro Gwanak-gu, Seoul, Korea
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(creator_code:org_t)
- 2021-04-27
- 2021
- Engelska.
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Ingår i: Medicina (Kaunas). - : MDPI. - 1010-660X .- 1648-9144. ; 57:5
- Relaterad länk:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background and Objectives: Aortic arch calcification (AoAC) is associated with a variety of cardiovascular complications. The measurement and grading of AoAC using posteroanterior (PA) chest X-rays are well established. The cardiothoracic ratio (CTR) can be simultaneously measured with PA chest X-rays and used as an index of cardiomegaly. The genetic and environmental contributions to the degree of the AoAC and CTR are not well understood. The purpose of this study was to investigate the effect of genetics and environmental factors on the AoAC and CTR.Materials and Methods: A total of 684 twins from the South Korean twin registry (261 monozygotic, MZ and 81 dizygotic, DZ pairs; mean age 38.6 ± 7.9 years, male/female = 264/420) underwent PA chest X-rays. Cardiovascular risk factors and anthropometric data were also collected. The AoAC and CTR were measured and graded using a standardized method. A structural equation method was used to calculate the proportion of variance explained by genetic and environmental factors behind AoAC and CTR.Results: The within-pair differences were low regarding the grade of AoAC, with only a few twin pairs showing large intra-pair differences. We found that the thoracic width showed high heritability (0.67, 95% CI: 0.59-0.73, p = 1). Moderate heritability was detected regarding cardiac width (0.54, 95% CI: 0.45-0.62, p = 0.572) and CTR (0.54, 95% CI: 0.44-0.62, p = 0.701). Conclusions: The heritable component was significant regarding thoracic width, cardiac width, and the CTR.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Aortic calcification
- atherosclerosis
- cardiothoracic ratio
- heritability
- twin study
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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