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Atypical presentati...
Atypical presentation of Neisseria meningitidis serogroup W disease is associated with the introduction of the 2013 strain
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- Säll, Olof, 1980- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Infectious Diseases
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- Stenmark, Bianca, 1987- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Laboratory Medicine, Clinical Microbiology
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- Jacobsson, Susanne, 1974- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Laboratory Medicine, Clinical Microbiology
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- Eriksson, Lorraine, 1990- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine, Clinical Microbiology
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- Thulin Hedberg, Sara (författare)
- Department of Laboratory Medicine, Clinical Microbiology
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- Hertting, Olof (författare)
- Karolinska Institutet
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- Fredlund, Hans (författare)
- Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Sundqvist, Martin, 1974- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Laboratory Medicine, Clinical Microbiology
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- Mölling, Paula, 1971- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Laboratory Medicine, Clinical Microbiology
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(creator_code:org_t)
- Cambridge University Press, 2021
- 2021
- Engelska.
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Ingår i: Epidemiology and Infection. - : Cambridge University Press. - 0950-2688 .- 1469-4409. ; 149
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Since 2015, the incidence of invasive meningococcal disease (IMD) caused by serogroup W (MenW) has increased in Sweden, due to the introduction of the 2013 strain belonging to clonal complex 11. The aim of this study was to describe the clinical presentation of MenW infections, in particular the 2013 strain, including genetic associations. Medical records of confirmed MenW IMD cases in Sweden during the years 1995-2019 (n = 113) were retrospectively reviewed and the clinical data analysed according to strain. Of all MenW patients, bacteraemia without the focus of infection was seen in 44%, bacteraemic pneumonia in 26%, meningitis in 13% and epiglottitis in 8%, gastrointestinal symptoms in 48% and 4% presented with petechiae. Phylogenetic analysis was used for possible links between genetic relationship and clinical picture. The 2013 strain infections, particularly in one cluster, were associated with more severe disease compared with other MenW infections. The patients with 2013 strain infections (n = 68) were older (52 years vs. 25 years for other strains), presented more often with diarrhoea as an atypical presentation (P = 0.045) and were more frequently admitted for intensive care (P = 0.032). There is a risk that the atypical clinical presentation of MenW infections, with predominantly gastrointestinal or respiratory symptoms rather than neck stiffness or petechiae, may lead to delay in life-saving treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Invasive meningococcal disease
- meningococcal disease
- Neisseria meningitidis
- serogroup W
- Sweden
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Säll, Olof, 1980 ...
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Stenmark, Bianca ...
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Jacobsson, Susan ...
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Eriksson, Lorrai ...
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Thulin Hedberg, ...
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Hertting, Olof
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Fredlund, Hans
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Sundqvist, Marti ...
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Mölling, Paula, ...
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- MEDICIN OCH HÄLSOVETENSKAP
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Epidemiology and ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet