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Sökning: WFRF:(Frank Stefanie) > (2020-2024) > The COVID-19 puzzle :

  • Osuchowski, Marcin F.Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research Center, Vienna, Austria (författare)

The COVID-19 puzzle : deciphering pathophysiology and phenotypes of a new disease entity

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Elsevier,2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-91711
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-91711URI
  • https://doi.org/10.1016/S2213-2600(21)00218-6DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:for swepub-publicationtype

Anmärkningar

  • Funding Agencies:Poland National Science Centre UMO-2020/01/0/NZ6/00218National Institute for Health Research (NIHR) CS-2016-16-011Berlin Institute of Health (BIH) Charite Clinician Scientist Programme  Charite-Universitatsmedizin Berlin  Berlin Institute of Health  German Research Foundation (DFG) SFB 1278316213987Netherlands Organization for Scientific Research (NWO)CIBERES in the context of CIBERESUCICOVID (Instituto de Salud Carlos III)  Ministero della Salute, Bando Ricerca COVID-19 COVID-2020-12371808
  • The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with devastating consequences. While the medical community has gained insight into the epidemiology of COVID-19, important questions remain about the clinical complexities and underlying mechanisms of disease phenotypes. Severe COVID-19 most commonly involves respiratory manifestations, although other systems are also affected, and acute disease is often followed by protracted complications. Such complex manifestations suggest that SARS-CoV-2 dysregulates the host response, triggering wide-ranging immuno-inflammatory, thrombotic, and parenchymal derangements. We review the intricacies of COVID-19 pathophysiology, its various phenotypes, and the anti-SARS-CoV-2 host response at the humoral and cellular levels. Some similarities exist between COVID-19 and respiratory failure of other origins, but evidence for many distinctive mechanistic features indicates that COVID-19 constitutes a new disease entity, with emerging data suggesting involvement of an endotheliopathy-centred pathophysiology. Further research, combining basic and clinical studies, is needed to advance understanding of pathophysiological mechanisms and to characterise immuno-inflammatory derangements across the range of phenotypes to enable optimum care for patients with COVID-19.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Winkler, Martin S.Department of Anaesthesiology, University of Göttingen Medical Center, Göttingen, Georg-August University of Göttingen, Göttingen, Germany (författare)
  • Skirecki, TomaszLaboratory of Flow Cytometry, Centre of Postgraduate Medical Education, Warsaw, Poland (författare)
  • Cajander, Sara,1980-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Infectious Diseases(Swepub:oru)scr (författare)
  • Shankar-Hari, ManuGuy's and St Thomas' NHS Foundation Trust, ICU support offices, St Thomas' Hospital, London, UK; School of Immunology & Microbial Sciences, Kings College London, London, UK (författare)
  • Lachmann, GunnarDepartment of Anesthesiology and Operative Intensive Care Medicine (CCM/CVK), Charité-Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health, Berlin, Germany (författare)
  • Monneret, GuillaumeHospices Civils de Lyon, Immunology Laboratory, Edouard Herriot Hospital, Lyon, France; Pathophysiology of Injury-Induced Immunosuppression, Equipe d'Accueil 7426, Université Claude Bernard Lyon 1 - bioMérieux - Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France (författare)
  • Venet, FabienneHospices Civils de Lyon, Immunology Laboratory, Edouard Herriot Hospital, Lyon, France; Pathophysiology of Injury-Induced Immunosuppression, Equipe d'Accueil 7426, Université Claude Bernard Lyon 1 - bioMérieux - Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France (författare)
  • Bauer, MichaelDepartment of Anesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital-Friedrich Schiller University, Jena, Germany (författare)
  • Brunkhorst, Frank M.Department of Anesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital-Friedrich Schiller University, Jena, Germany; Center for Clinical Studies, Jena University Hospital-Friedrich Schiller University, Jena, Germany (författare)
  • Weis, SebastianDepartment of Anesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital-Friedrich Schiller University, Jena, Germany; Institute for Infectious Disease and Infection Control, Jena University Hospital-Friedrich Schiller University, Jena, Germany (författare)
  • Garcia-Salido, AlbertoPediatric Critical Care Unit, Hospital Infantil Universitario Niño Jesús, Madrid, Spain (författare)
  • Kox, MatthijsDepartment of Intensive Care Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands (författare)
  • Cavaillon, Jean-MarcAgence Nationale de la Recherche, Paris, France (författare)
  • Uhle, FlorianDepartment of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany (författare)
  • Weigand, Markus A.Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany (författare)
  • Flohé, Stefanie B.Department of Trauma, Hand, and Reconstructive Surgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany (författare)
  • Wiersinga, W. JoostDivision of Infectious Diseases and Center of Experimental and Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands (författare)
  • Almansa, RaquelGroup for Biomedical Research in Sepsis, Hospital Universitario Río Hortega de Valladolid, Instituto de Investigación Biomédica de Salamanca, Salamanca, Spain; Centro de Investigación Biomedica En Red-Enfermedades Respiratorias, Instituto de salud Carlos III, Madrid, Spain (författare)
  • de la Fuente, AmandaGroup for Biomedical Research in Sepsis, Hospital Universitario Río Hortega de Valladolid, Instituto de Investigación Biomédica de Salamanca, Salamanca, Spain (författare)
  • Martin-Loeches, IgnacioMultidisciplinary Intensive Care Research Organization, St James's Hospital, Dublin, Ireland (författare)
  • Meisel, ChristianInstitute for Medical Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany; Department of Immunology, Labor Berlin-Charité Vivantes, Berlin, Germany (författare)
  • Spinetti, ThibaudDepartment of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (författare)
  • Schefold, Joerg C.Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (författare)
  • Cilloniz, CatiaPneumology Department, Respiratory Institute, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, ICREA, CIBERESUCICOVID, Spain (författare)
  • Torres, AntoniDivision of Infectious Diseases and Center of Experimental and Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands; Pneumology Department, Respiratory Institute, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, ICREA, CIBERESUCICOVID, Spain; SGR 911-ICREA Academia, Barcelona, Spain (författare)
  • Giamarellos-Bourboulis, Evangelos J.4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece (författare)
  • Ferrer, RicardCentro de Investigación Biomedica En Red-Enfermedades Respiratorias, Instituto de salud Carlos III, Madrid, Spain; Intensive Care Department and Shock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain (författare)
  • Girardis, MassimoDepartment of Anesthesia and Intensive Care, University Hospital of Modena, Modena, Italy (författare)
  • Cossarizza, AndreaDepartment of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy (författare)
  • Netea, Mihai G.Department of Intensive Care Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, Romania; Department for Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany (författare)
  • van der Poll, TomDivision of Infectious Diseases and Center of Experimental and Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands (författare)
  • Bermejo-Martín, Jesús F.Group for Biomedical Research in Sepsis, Hospital Universitario Río Hortega de Valladolid, Instituto de Investigación Biomédica de Salamanca, Salamanca, Spain; Centro de Investigación Biomedica En Red-Enfermedades Respiratorias, Instituto de salud Carlos III, Madrid, Spain (författare)
  • Rubio, IgnacioDepartment of Anesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital-Friedrich Schiller University, Jena, Germany (författare)
  • Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research Center, Vienna, AustriaDepartment of Anaesthesiology, University of Göttingen Medical Center, Göttingen, Georg-August University of Göttingen, Göttingen, Germany (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:The Lancet Respiratory Medicine: Elsevier9:6, s. 622-6422213-26002213-2619

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