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Quantitative T2* im...
Quantitative T2* imaging of iron overload in a non-dedicated center - Normal variation, repeatability and reader variation
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- Lidén, Mats, 1976- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Radiology
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- Adrian, David (författare)
- Department of Radiology, Örebro University Hospital, Region Örebro County, Sweden
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- Widell, Jonas (författare)
- Department of Radiology, Örebro University Hospital, Region Örebro County, Sweden
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- Uggla, Bertil, 1962- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medicine
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- Thunberg, Per, 1968- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Physics
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: European journal of radiology open. - : Elsevier. - 2352-0477. ; 8
- Relaterad länk:
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https://doi.org/10.1...
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http://www.ejropen.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Patients with transfusion dependent anemia are at risk of complications from iron overload. Quantitative T2* magnetic resonance imaging (MRI) is the best non-invasive method to assess iron deposition in the liver and heart and to guide chelation therapy.Purpose: To investigate the image quality and inter-observer variations in T2* measurements of the myocardium and the liver, and to obtain the lower limit of cardiac and hepatic quantitative T2* values in patients without suspicion of iron overload.Material and methods: Thirty-eight patients referred for cardiac MRI were prospectively included in the study. Three patients were referred with, and 35 without suspicion of iron overload. Quantitative T2* parametric maps were obtained on a 1.5 T MRI system in the cardiac short axis and liver axial view. Two readers independently assessed the image quality and the representative and the lowest T2* value in the myocardium and the liver.Results: The normal range of representative T2* values in the myocardium and liver was 24-45 ms and 14-37 ms, respectively. None of the 35 participants (0 %, 95 % confidence interval 0-11 %) in the normal reference group demonstrated representative T2* values below previously reported lower limits in the myocardium (20 ms) or the liver (8 ms). Focal myocardial areas with T2* values near the lower normal range, 19-20 ms, were seen in two patients. The readers generally reported good image quality.Conclusion: T2* imaging for assessing iron overload can be performed in a non-dedicated center with sufficient image quality.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Heart
- Iron overload
- Liver
- Quantitative MRI
- T2 star
- Thalassemia
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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