Inflammatory and coagulatory markers and exposure to different size fractions of particle mass, number and surface area air concentrations in the Swedish hard metal industry, in particular to cobalt

Andersson, Lena,1965-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Occupational and Environmental Medicine,,Inflammatory Response and Infection Susceptibility Centre (iRiSC) (författare)

Funding Agencies:Örebro University ORU 2.2.1-4060/2013ALF-agreement ALFGBG-872511
Purpose: To study the relationship between inhalation of airborne particles and cobalt in the Swedish hard metal industry and markers of inflammation and coagulation in blood.Methods: Personal sampling of inhalable cobalt and dust were performed for subjects in two Swedish hard metal plants. Stationary measurements were used to study concentrations of inhalable, respirable, and total dust and cobalt, PM10 and PM2.5, the particle surface area and the particle number concentrations. The inflammatory markers CC16, TNF, IL-6, IL-8, IL-10, SAA and CRP, and the coagulatory markers FVIII, vWF, fibrinogen, PAI-1 and D-dimer were measured. A complete sampling was performed on the second or third day of a working week following a work-free weekend, and additional sampling was taken on the fourth or fifth day. The mixed model analysis was used, including covariates.Results: The average air concentration of inhalable dust and cobalt were 0.11 mg/m3 and 0.003 mg/m3, respectively. For some mass-based exposure measures of cobalt and total dust, statistically significant increased levels of FVIII, vWF and CC16 were found.Conclusions: The observed relationships between particle exposure and coagulatory biomarkers may indicate an increased risk of cardiovascular disease.

Hedbrant, Alexander,1987-Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC)(Swepub:oru)arht (författare)
Persson, Alexander,1978-Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC)(Swepub:oru)axpn (författare)
Bryngelsson, Ing-LissDepartment of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (författare)
Sjögren, BengtKarolinska Institutet (författare)
Stockfelt, LeoOccupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Occupational and Environmental Medicine, and Sahlgrenska University Hospital, Gothenburg, Sweden (författare)
Särndahl, Eva,1963-Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC)(Swepub:oru)easl (författare)
Westberg, Håkan,1949-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Occupational and Environmental Medicine,Inflammatory Response and Infection Susceptibility Centre (iRiSC)(Swepub:oru)hwg (författare)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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