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Extractable Organof...
Extractable Organofluorine Analysis in Pooled Human Serum and Placental Tissue Samples from an Austrian Subpopulation : A Mass Balance Analysis Approach
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- Kaiser, Andreas-Marius (författare)
- Environment Agency Austria, Vienna, Austria; Institute of Medical Genetics, Center for Pathobiochemistry and Genetics, Medical University of Vienna, Vienna, Austria
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- Forsthuber, Martin (författare)
- Institute of Medical Genetics, Center for Pathobiochemistry and Genetics, Medical University of Vienna, Vienna, Austria; Department of Environmental Health, Center for Public Health, Medical University of Vienna, Vienna, Austria
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- Aro, Rudolf, 1992- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Centre (MTM)
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- Kärrman, Anna, 1975- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Centre (MTM)
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- Gundacker, Claudia (författare)
- Institute of Medical Genetics, Center for Pathobiochemistry and Genetics, Medical University of Vienna, Vienna, Austria
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- Zeisler, Harald (författare)
- Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria
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- Foessleitner, Philipp (författare)
- Department of Gynecology and Obstetrics, University Hospital St. Poelten, St. Poelten, Austria
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- Salzer, Hans (författare)
- Clinic for Pediatrics and Adolescent Medicine, University Hospital Tulln, Tulln, Austria
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- Hartmann, Christina (författare)
- Environment Agency Austria, Vienna, Austria
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- Uhl, Maria (författare)
- Environment Agency Austria, Vienna, Austria
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- Yeung, Leo W. Y., 1981- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Centre (MTM)
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(creator_code:org_t)
- 2021-06-16
- 2021
- Engelska.
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 55:13, s. 9033-9042
- Relaterad länk:
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https://doi.org/10.1...
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https://pubs.acs.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Embryos and fetuses are of major concern due to their high vulnerability. Previous studies demonstrated that human exposure to per- and polyfluoroalkyl substances (PFAS) may be underestimated because only a limited number of known PFAS can be measured. This investigation studied the total PFAS exposure by measuring the extractable organofluorine (EOF) in pooled maternal serum, placental tissue, and cord serum samples (total number of pooled samples: n = 45). The EOF was analyzed using combustion ion chromatography, and the concentrations of known PFAS were determined using ultraperformance liquid chromatography coupled with a tandem mass spectrometer. Using a mass balance analysis approach, the amount of unknown PFAS was estimated between the levels of known PFAS and EOF. The EOF levels ranged from 2.85 to 7.17 ng F/mL (21 PFAS were quantified) in the maternal serum, from 1.02 to 1.85 ng F/g (23 PFAS were quantified) in the placental tissue, and from 1.2 to 2.10 ng F/mL (18 PFAS were quantified) in the cord serum. An average of 24, 51, and 9% of EOF is unidentified in the maternal serum, placental tissue, and cord serum, respectively. The results show that the levels of unidentified EOF are higher in the placental tissue, suggesting accumulation or potential transformation of precursors in the placenta.
Ämnesord
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Nyckelord
- Cord serum
- maternal serum
- per- and polyfluoroalkyl substances
- placental tissue
- unidentified organofluorine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Kaiser, Andreas- ...
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Forsthuber, Mart ...
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Aro, Rudolf, 199 ...
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Kärrman, Anna, 1 ...
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Gundacker, Claud ...
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Zeisler, Harald
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Foessleitner, Ph ...
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Salzer, Hans
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Hartmann, Christ ...
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Uhl, Maria
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Yeung, Leo W. Y. ...
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Environmental Sc ...
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Örebro universitet