Patients with symptomatic permanent atrial fibrillation show quantitative signs of pain sensitisation

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Jackson, AdamDepartment of Cardiology, Örebro University Hospital, Sweden, Örebro, Sweden (författare)

Patients with symptomatic permanent atrial fibrillation show quantitative signs of pain sensitisation

Artikel/kapitelEngelska2021

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2021-06-17
BMJ Publishing Group Ltd,2021
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LIBRIS-ID:oai:DiVA.org:oru-92492
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-92492URI
https://doi.org/10.1136/openhrt-2021-001699DOI

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Språk:engelska
Sammanfattning på:engelska

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Funding Agencies:Center for Neuroplasticity and Pain (CNAP) Danmarks Grundforskningsfond DNRF121
OBJECTIVE: Most patients with atrial fibrillation (AF) report symptoms, while one-third are asymptomatic. We hypothesised that sensory processing, in particular pain, differs in patients with symptomatic and asymptomatic AF.METHODS: Thirty individuals with permanent AF (15 symptomatic and 15 asymptomatic) completed the Atrial Fibrillation 6 (AF6) and short form 36 Health Survey questionnaires and underwent quantitative pain sensitisation testing using pressure algometry at the sternum (referred pain area) and the tibialis anterior muscle (generalised pain area). The primary objective was to assess differences in pressure pain thresholds (PPT), temporal summation of pain (TSP) and conditioned pain modulation (CPM) in the two groups. The secondary objective was to determine association of demographic and clinical parameters to measures of pain sensitisation.RESULTS: The symptomatic group had lower PPTs at both tibialis (p=0.004) and sternum (p=0.01), and impaired CPM (p=0.025) and facilitated TSP (p=0.008) at the tibialis but not sternum, compared with the asymptomatic group. The AF6 sum score was negatively correlated to PPT on both tibialis (r=-0.50, p=0.005) and sternum (r=-0.42, p=0.02) and positively correlated to TSP on both tibialis (r=0.57, p=0.001) and sternum (r=0.45, p=0.01), but not to CPM. The physical component summary score was positively correlated to the PPT on both tibialis (r=0.52, p=0.003) and sternum (r=0.40, p=0.03) and negatively to TSP on the tibialis (r=-0.53, p=0.003) but not sternum.CONCLUSIONS: Patients with symptomatic AF exhibit lower pain tolerance than patients with asymptomatic AF, as well as impaired pain inhibitory control and facilitated summation of pain, indicating that pain sensitisation may be of importance in symptomatic AF.Trial registration numberNCT04649437.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
atrial fibrillation
chest pain
obesity

Biuppslag (personer, institutioner, konferenser, titlar ...)

Fröbert, Ole,1964-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology(Swepub:oru)oft (författare)
Boye Larsen, DennisDepartment of Health Science and Technology and the Center for Sensory-Motor Interaction/Center for Neuroplasticity and Pain, Faculty of Medicine, Aalborg University, Aalborg, Denmark (författare)
Arendt-Nielsen, LarsDepartment of Health Science and Technology and the Center for Sensory-Motor Interaction/Center for Neuroplasticity and Pain, Faculty of Medicine, Aalborg University, Aalborg, Denmark (författare)
Björkenheim, Anna,1980-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Cardiology(Swepub:oru)anbm (författare)
Department of Cardiology, Örebro University Hospital, Sweden, Örebro, SwedenInstitutionen för medicinska vetenskaper (creator_code:org_t)

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Ingår i:Open heart: BMJ Publishing Group Ltd8:12053-3624

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Av författaren/redakt...: Jackson, Adam; Fröbert, Ole, 19 ...; Boye Larsen, Den ...; Arendt-Nielsen, ...; Björkenheim, Ann ...

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