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Conjugated C-6 hydr...
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Petersen, Anders Ø.Department of Health Technology, Technical University of Denmark, Lyngby, Denmark
(författare)
Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-06-24
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Nature Publishing Group,2021
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-92680
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-92680URI
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https://doi.org/10.1038/s41598-021-91482-yDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agency:Metagenopolis grant ANR-11-DPBS-0001
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Knowledge about in vivo effects of human circulating C-6 hydroxylated bile acids (BAs), also called muricholic acids, is sparse. It is unsettled if the gut microbiome might contribute to their biosynthesis. Here, we measured a range of serum BAs and related them to markers of human metabolic health and the gut microbiome. We examined 283 non-obese and obese Danish adults from the MetaHit study. Fasting concentrations of serum BAs were quantified using ultra-performance liquid chromatography-tandem mass-spectrometry. The gut microbiome was characterized with shotgun metagenomic sequencing and genome-scale metabolic modeling. We find that tauro- and glycohyocholic acid correlated inversely with body mass index (P = 4.1e-03, P = 1.9e-05, respectively), waist circumference (P = 0.017, P = 1.1e-04, respectively), body fat percentage (P = 2.5e-03, P = 2.3e-06, respectively), insulin resistance (P = 0.051, P = 4.6e-4, respectively), fasting concentrations of triglycerides (P = 0.06, P = 9.2e-4, respectively) and leptin (P = 0.067, P = 9.2e-4). Tauro- and glycohyocholic acids, and tauro-a-muricholic acid were directly linked with a distinct gut microbial community primarily composed of Clostridia species (P = 0.037, P = 0.013, P = 0.027, respectively). We conclude that serum conjugated C-6-hydroxylated BAs associate with measures of human metabolic health and gut communities of Clostridia species. The findings merit preclinical interventions and human feasibility studies to explore the therapeutic potential of these BAs in obesity and type 2 diabetes.
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Julienne, HannaDepartment of Computational Biology-USR 3756 CNRS, Institut Pasteur, Paris, France
(författare)
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Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)tihn
(författare)
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Sen, ParthoTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
(författare)
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Fan, YongNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
(författare)
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Pedersen, Helle KroghNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Clinical Microbiomics A/S, Copenhagen, Denmark
(författare)
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Jäntti, SirkkuDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
(författare)
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Hansen, Tue H.Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
(författare)
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Nielsen, TrineNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
(författare)
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Jørgensen, TorbenDepartment of Public Health, Faculty of Health and Medical Sciences , University of Copenhagen, Copenhagen, Denmark; Faculty of Medicine, Aalborg University, Aalborg East, Denmark
(författare)
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Hansen, TorbenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
(författare)
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Myers, Pernille NeveDepartment of Health Technology, Technical University of Denmark, Lyngby, Denmark
(författare)
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Nielsen, H. BjørnClinical Microbiomics A/S, Copenhagen, Denmark
(författare)
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Ehrlich, S. DuskoDepartment of Computational Biology-USR 3756 CNRS, Institut Pasteur, Paris, France
(författare)
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Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland(Swepub:oru)moc
(författare)
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Pedersen, OlufNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
(författare)
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Department of Health Technology, Technical University of Denmark, Lyngby, DenmarkDepartment of Computational Biology-USR 3756 CNRS, Institut Pasteur, Paris, France
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Scientific Reports: Nature Publishing Group11:12045-2322
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Petersen, Anders ...
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Julienne, Hanna
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Hyötyläinen, Tuu ...
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Sen, Partho
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Fan, Yong
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Jäntti, Sirkku
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Hansen, Tue H.
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Nielsen, Trine
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Jørgensen, Torbe ...
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Hansen, Torben
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Myers, Pernille ...
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Nielsen, H. Bjør ...
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Ehrlich, S. Dusk ...
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Pedersen, Oluf
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