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Effectiveness of Third-Class Biologic Treatment in Crohn's Disease : A Multi-Center Retrospective Cohort Study

Albshesh, Ahmad (författare)
Sheba Medical Center, Department of Gastroenterology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Taylor, Joshua (författare)
Department of Gastroenterology, Montreal General Hospital, Montreal QC, Canada
Savarino, Edoardo, V (författare)
Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy
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Truyens, Marie (författare)
IBD Unit, Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium
Armuzzi, Alessandro (författare)
IBD Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy
Ribaldone, Davide G. (författare)
Division of Gastroenterology, Department of Medical Sciences, University of Turin, Turin, Italy
Shitrit, Ariella Bar-Gil (författare)
Shaare Zedek Medical Center, Faculty of Medicine, Digestive Diseases Institute, Hebrew University of Jerusalem, Jerusalem, Israel
Fibelman, Morine (författare)
Tel Aviv Medical Center, Department of Gastroenterology and Liver Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Molander, Pauliina (författare)
Abdominal Center, Department of Gastroenterology, Helsinki University Hospital, Helsinki, Finland
Liefferinckx, Claire (författare)
Department of Gastroenterology, Erasme University Hopital, Brussels, Belgium
Nancey, Stephane (författare)
Department of Gastroenterology, Hospices Civils de Lyon, University Claude Bernard Lyon, Lyon, France; INSERM, U1111, CIRI, Lyon, France
Korani, Mohamed (författare)
Division of Gastroenterology, The Pennine Acute Hospitals NHS Trust, Manchester, UK; Manchester Academic Health Sciences, University of Manchester, Manchester, UK
Rutka, Mariann (författare)
First Department of Medicine, University of Szeged, Szeged, Hungary
Barreiro-de Acosta, Manuel (författare)
IBD Unit, Gastroenterology Department, University Hospital of Santiago de Compostela, Santiago, Spain
Domislovic, Viktor (författare)
Department of Gastroenterology, Hepatology, and Nutrition, University Hospital Centre Zagreb, Zagreb, Croatia
Suris, Gerard (författare)
Digestive System Service, Bellvitge University Hospital, Catalan Institute of Health, Barcelona, Spain
Eriksson, Carl, 1981- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology
Alves, Catarina (författare)
Department of Gastroenterology, Centro Hospitalar São João, Porto, Portugal
Mpitouli, Afroditi (författare)
Department of Gastroenterology, Venizeleion General Hospital, Heraklion, Crete, Greece
di Jiang, Caroline (författare)
Department of Gastroenterology, Addenbrooke’s Hospital, Cambridge University Hospitals, Cambridge, UK
Tepes, Katja (författare)
University Medical Centre Ljubljana, Department of Gastroenterology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
Coletta, Marina (författare)
Department of Hepatology and Clinical Gastroenterology, ASST Santi Paolo e Carlo-Ospedale San Polo Universitario Milano Mariabeatrice, Milan, Italy
Foteinogiannopoulou, Kalliopi (författare)
Department of Gastroenterology, University Hospital of Heraklion, Crete, Greece
Gisbert, Javier P. (författare)
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid, Madrid, Spain
Amir-Barak, Hadar (författare)
IBD Center, Division of Gastroenterology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Attauabi, Mohamed (författare)
Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark
Seidelin, Jakob (författare)
Department of Gastroenterology, Herlev University Hospital, Copenhagen, Denmark
Afif, Waqqas (författare)
Department of Gastroenterology, Montreal General Hospital, Montreal QC, Canada
Marinelli, Carla (författare)
Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy
Lobaton, Triana (författare)
IBD Unit, Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium
Pugliese, Daniela (författare)
IBD Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy
Maharshak, Nitsan (författare)
Tel Aviv Medical Center, Department of Gastroenterology and Liver Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Cremer, Anneline (författare)
Department of Gastroenterology, Erasme University Hopital, Brussels, Belgium
Limdi, Jimmy K. (författare)
Division of Gastroenterology, The Pennine Acute Hospitals NHS Trust, Manchester, UK; Manchester Academic Health Sciences, University of Manchester, Manchester, UK
Molnár, Tamás (författare)
First Department of Medicine, University of Szeged, Szeged, Hungary
Otero-Alvarin, Borja (författare)
IBD Unit, Gastroenterology Department, University Hospital of Santiago de Compostela, Santiago, Spain
Krznaric, Zeljko (författare)
Department of Gastroenterology, Hepatology, and Nutrition, University Hospital Centre Zagreb, Zagreb, Croatia
Magro, Fernando (författare)
Department of Gastroenterology, Centro Hospitalar São João, Porto, Portugal
Karmiris, Konstantinos (författare)
Department of Gastroenterology, Venizeleion General Hospital, Heraklion, Crete, Greece
Raine, Tim (författare)
Department of Gastroenterology, Addenbrooke’s Hospital, Cambridge University Hospitals, Cambridge, UK
Drobne, David (författare)
University Medical Centre Ljubljana, Department of Gastroenterology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
Koutroubakis, Ioannis (författare)
Department of Gastroenterology, University Hospital of Heraklion, Crete, Greece
Chaparro, Maria (författare)
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid, Madrid, Spain
Yanai, Henit (författare)
IBD Center, Division of Gastroenterology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Burisch, Johan (författare)
Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark
Kopylov, Uri (författare)
Sheba Medical Center, Department of Gastroenterology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
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 (creator_code:org_t)
2021-06-29
2021
Engelska.
Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 10:13
Relaterad länk:
https://doi.org/10.3...
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https://www.mdpi.com...
https://urn.kb.se/re...
https://doi.org/10.3...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Multiple studies have described the effectiveness of ustekinumab (UST) and vedolizumab (VDZ) in patients with Crohn's disease (CD) failing anti- Tumor necrosis factors (TNFs); however, the effectiveness of VDZ or UST as a third-class biologic has not yet been described.Aims and Methods: In this retrospective multicenter cohort study, we aimed to investigate the effectiveness of VDZ and UST as a third-class biologic in patients with CD.Results: Two-hundred and four patients were included; 156/204 (76%) patients received VDZ as a second- and UST as a third-class therapy (group A); the remaining 48/204 (24%) patients received UST as a second- and VDZ as a third-class therapy (group B). At week 16-22, 87/156 (55.5%) patients and 27/48 (56.2%) in groups A and B, respectively, responded to treatment (p = 0.9); 41/156 (26.2%) and 15/48 (31.2%) were in clinical remission (p = 0.5). At week 52; 89/103 (86%) patients and 25/29 (86.2%) of the patients with available data had responded to third-class treatment in groups A and B, respectively (p = 0.9); 31/103 (30%) and 47/29 (24.1%) were in clinical remission (p = 0.5).Conclusion: Third-class biological therapy was effective in more than half of the patients with CD. No differences in effectiveness were detected between the use of VDZ and UST as a third-class agent.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

Nyckelord

Crohn's disease
anti-TNF failure
treatment response
treatment failure
ustekinumab
vedolizumab

Publikations- och innehållstyp

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