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  • Ruuth, MaijaAtherosclerosis Research Laboratory, Wihuri Research Institute, Haartmaninkatu, Helsinki, Finland; Research Programs Unit, Faculty of Medicine, University of Helsinki, Finland (author)

Overfeeding Saturated Fat Increases LDL (Low-Density Lipoprotein) Aggregation Susceptibility While Overfeeding Unsaturated Fat Decreases Proteoglycan-Binding of Lipoproteins

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • Lippincott Williams & Wilkins,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-94085
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-94085URI
  • https://doi.org/10.1161/ATVBAHA.120.315766DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies:Jenny and Antti Wihuri FoundationFinnish Foundation for Cardiovascular ResearchBritish Heart Foundation Senior Research Fellowship FS/15/56/31645Alfred Kordelin Foundation Jalmari and Rauha Ahokas FoundationPaulo FoundationFinnish Medical FoundationSigrid Juselius FoundationEVO foundation
  • OBJECTIVE: We recently showed that measurement of the susceptibility of LDL (low-density lipoprotein) to aggregation is an independent predictor of cardiovascular events. We now wished to compare effects of overfeeding different dietary macronutrients on LDL aggregation, proteoglycan-binding of plasma lipoproteins, and on the concentration of oxidized LDL in plasma, 3 in vitro parameters consistent with increased atherogenicity.Approach and Results: The participants (36 subjects; age, 48±10 years; body mass index, 30.9±6.2 kg/m2) were randomized to consume an extra 1000 kcal/day of either unsaturated fat, saturated fat, or simple sugars (CARB) for 3 weeks. We measured plasma proatherogenic properties (susceptibility of LDL to aggregation, proteoglycan-binding, oxidized LDL) and concentrations and composition of plasma lipoproteins using nuclear magnetic resonance spectroscopy, and in LDL using liquid chromatography mass spectrometry, before and after the overfeeding diets. LDL aggregation increased in the saturated fat but not the other groups. This change was associated with increased sphingolipid and saturated triacylglycerols in LDL and in plasma and reduction of clusterin on LDL particles. Proteoglycan binding of plasma lipoproteins decreased in the unsaturated fat group relative to the baseline diet. Lipoprotein properties remained unchanged in the CARB group.CONCLUSIONS: The type of fat during 3 weeks of overfeeding is an important determinant of the characteristics and functional properties of plasma lipoproteins in humans.REGISTRATION: URL: http://www.clinicaltrials.gov; Unique identifier NCT02133144.

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  • Lahelma, MariMinerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Medicine, University of Helsinki and Helsinki University Hospital, Finland (author)
  • Luukkonen, Panu K.Minerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Medicine, University of Helsinki and Helsinki University Hospital, Finland (author)
  • Lorey, Martina B.Atherosclerosis Research Laboratory, Wihuri Research Institute, Haartmaninkatu, Helsinki, Finland (author)
  • Qadri, SamiMinerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Medicine, University of Helsinki and Helsinki University Hospital, Finland (author)
  • Sädevirta, SanjaMinerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Medicine, University of Helsinki and Helsinki University Hospital, Finland (author)
  • Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)tihn (author)
  • Kovanen, Petri T.Atherosclerosis Research Laboratory, Wihuri Research Institute, Haartmaninkatu, Helsinki, Finland (author)
  • Hodson, LeanneOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, and National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital Trusts, United Kingdom (author)
  • Yki-Järvinen, HanneleMinerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Medicine, University of Helsinki and Helsinki University Hospital, Finland (author)
  • Öörni, KatariinaAtherosclerosis Research Laboratory, Wihuri Research Institute, Haartmaninkatu, Helsinki, Finland (author)
  • Atherosclerosis Research Laboratory, Wihuri Research Institute, Haartmaninkatu, Helsinki, Finland; Research Programs Unit, Faculty of Medicine, University of Helsinki, FinlandMinerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Medicine, University of Helsinki and Helsinki University Hospital, Finland (creator_code:org_t)

Related titles

  • In:Arteriosclerosis, Thrombosis and Vascular Biology: Lippincott Williams & Wilkins41:11, s. 2823-28361079-56421524-4636

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