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Orofacial Granuloma...
Orofacial Granulomatosis associated with Crohn's Disease : a multi-centre case series
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- Phillips, Frank (författare)
- NIHR Nottingham Digestive Diseases Biomedical Research Centre, Nottingham University Hospitals, Nottingham, UK
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- Verstockt, Bram (författare)
- University Hospitals Leuven, Gastroenterology and Hepatology, Leuven, Belgium; KU Leuven, Chronic Diseases, Metabolism and Ageing, TARGID-IBD unit, Leuven, Belgium
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- Sladek, Malgorzata (författare)
- Department of Pediatrics, Gastroenterology and Nutrition, Jagiellonian University Medical College, Krakow, Poland
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- de Boer, Nanne (författare)
- Amsterdam UMC, Department of Gastroenterology and Hepatology, Amsterdam UMC, Vrije Universiteit Amsterdam, AGEM Research Institute, Amsterdam, The Netherlands
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- Katsanos, Konstantinos (författare)
- Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Ioannina School of Health Sciences, Ioannina, Greece
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- Karmiris, Konstantinos (författare)
- Department of Gastroenterology, Venizeleio General Hospital, Heraklion, Greece
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- Albshesh, Ahmad (författare)
- Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Israel, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
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- Erikson, Carl, 1981- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology
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- Bergemalm, Daniel, 1977- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology
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- Molnar, Tamas (författare)
- First Department of Medicine, University of Szeged, Szeged, Hungary
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- Ellul, Pierre (författare)
- Department of Medicine, Division of Gastroenterology, Mater Dei hospital, Msida, Malta
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ECCO CONFER Investigators, - (bidragsgivare)
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(creator_code:org_t)
- 2021-09-08
- 2022
- Engelska.
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Ingår i: Journal of Crohn's & Colitis. - : Elsevier. - 1873-9946 .- 1876-4479. ; 16:3, s. 430-435
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Orofacial granulomatosis (OFG) is a rare syndrome that may be associated with Crohn's disease (CD). We aimed to characterise this relationship and the management options in the biologic era.METHODS: This multicentre case series was supported by the European Crohn's and Colitis Organisation (ECCO), and performed as part of the Collaborative Network of Exceptionally Rare case reports (CONFER) project. Clinical data were recorded in a standardised collection form.RESULTS: This report includes 28 patients with OFG associated with CD: 14 males (mean age of 32 years, ±12.4 SD) and 14 females (40.3 years, ±21.0 SD). Non-oral upper gastrointestinal tract involvement was seen in 6 cases and perianal disease in 11. The diagnosis of OFG was made prior to CD diagnosis in 2 patients, concurrently in 8 and after CD diagnosis in 18. The distribution of OFG involved the lips in 16 cases and buccal mucosa in 18. Pain was present in 25 cases, with impaired swallowing or speaking in 6. Remission was achieved in 23 patients, notably with the use of anti-TNFs in 9 patients, vedolizumab in 1, ustekinumab in 1 and thalidomide in 2. A further 5 cases were resistant to therapies including anti-TNFs.CONCLUSION: OFG associated with CD may occur before, concurrently or after the diagnosis of CD. Perianal and UGI disease are common associations and there is a significant symptom burden in many. Remission can be obtained with a variety of immunosuppressive treatments, including several CD approved biologicals.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Crohn’s disease
- Orofacial granulomatosis
- Ulcerative Colitis
- inflammatory bowel disease
- oral Crohn’s disease
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- ref (ämneskategori)
- art (ämneskategori)
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Phillips, Frank
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Verstockt, Bram
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Sladek, Malgorza ...
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de Boer, Nanne
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Katsanos, Konsta ...
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Karmiris, Konsta ...
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Albshesh, Ahmad
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Erikson, Carl, 1 ...
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Bergemalm, Danie ...
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Molnar, Tamas
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Ellul, Pierre
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ECCO CONFER Inve ...
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Örebro universitet