Association between adult attention-deficit hyperactivity disorder and generalised joint hypermobility: A cross-sectional case control comparison

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Glans, Martin,1985-Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Centre,Orebro Univ, Sweden (författare)

Association between adult attention-deficit hyperactivity disorder and generalised joint hypermobility : A cross-sectional case control comparison

Artikel/kapitelEngelska2021

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Elsevier,2021
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LIBRIS-ID:oai:DiVA.org:oru-94608
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-94608URI
https://doi.org/10.1016/j.jpsychires.2021.07.006DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:147692053URI
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-180265URI

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Språk:engelska
Sammanfattning på:engelska

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Funding agencies:Bror Gadelius minnesfondÖrebro University
Funding Agencies|Swedish Research CouncilSwedish Research CouncilEuropean Commission [K2012-62X-22130-04-6]; Bror Gadelius minnesfond; Odrebro University
Growing evidence suggests an unexpected association between generalised joint hypermobility (GJH) and several psychiatric conditions, and a shared pathophysiology has been proposed. No previous studies on adult attention-deficit/hyperactivity disorder (ADHD) are available. This study aimed to evaluate the association between adult ADHD and GJH. A total of 431 adults with ADHD and 417 non-ADHD controls were included in this cross-sectional comparative study. GJH was assessed by physical examination following the Beighton scoring system (BSS). Furthermore, musculoskeletal symptoms and skin abnormalities were queried to create a proxy for symptomatic GJH (e.g., Hypermobility spectrum disorders and Ehlers-Danlos syndrome) to differentiate this from non-specified GJH defined by BSS only. Logistic regression examined the influence of ADHD and candidate covariates (age, sex, ethnicity) on GJH and symptomatic GJH, respectively. ADHD was significantly associated with GJH, as defined by the BSS, with adjusted odds ratios of 4.7 (95% confidence interval [CI] 3.0-7.2, p < .005). Likewise, ADHD was significantly associated with symptomatic GJH, as defined by the BSS and additional symptoms, with adjusted odds ratios of 6.9 (CI 95% 4.1-11.9, p < .005). Our results suggest that GJH may represent a marker for an underlying systemic disorder involving both connective tissue and the central nervous system. GJH with additional musculoskeletal symptoms and/or skin abnormalities has a considerable stronger link to adult ADHD than non-specified GJH has, and may need awareness in ADHD management. Future studies should investigate the mechanisms behind this association and how comorbid GJH affects ADHD outcome.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
Attention deficit disorder with hyperactivity
Biomarkers
Comorbidity
Ehlers-Danlos syndrome
Hypermobility
Joint instability

Biuppslag (personer, institutioner, konferenser, titlar ...)

Thelin, Nils,1970-Division of Psychiatry, Linköping University Hospital, Linköping, Sweden,Region Östergötland, Psykiatriska kliniken i Linköping(Swepub:liu)nilth56 (författare)
Humble, Mats B.,1952-Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Centre,Orebro Univ, Sweden; Orebro Univ, Sweden(Swepub:oru)mhe (författare)
Elwin, Marie,1953-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,University Health Care Research Centre,Orebro Univ, Sweden(Swepub:oru)mien (författare)
Bejerot, Susanne,1955-Örebro universitet,Institutionen för medicinska vetenskaper,Faculty of Medicine and Health, University Health Care Research Centre, Örebro University Campus USÖ, Örebro, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden,Orebro Univ, Sweden; Orebro Univ, Sweden; Karolinska Inst, Sweden(Swepub:oru)sebt (författare)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

Ingår i:Journal of Psychiatric Research: Elsevier143, s. 334-3400022-39561879-1379

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