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Sökning: WFRF:(Grubb Anders) > (2020-2023) > Performance of crea...

Performance of creatinine-based equations to estimate glomerular filtration rate with a methodology adapted to the context of drug dosage adjustment

Delanaye, Pierre (författare)
Department of Nephrology-Dialysis-Transplantation, University of Liège (ULg CHU), CHU Sart Tilman, Liège, Belgium; Department of Nephrology-Dialysis-Apheresis, Hopital Universitaire Caremeau, Nimes, France
Björk, Jonas (författare)
Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital
Courbebaisse, Marie (författare)
Physiology Department, Georges Pompidou European Hospital, Assistance Publique Hôpitaux de Paris, Paris Descartes University, INSERM U1151-CNRS UMR8253, Paris, France.,Paris Diderot University
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Couzi, Lionel (författare)
CHU de Bordeaux, Nephrologie - Transplantation - Dialyse, Université de Bordeaux, CNRS-UMR 5164 Immuno ConcEpT, France.
Ebert, Natalie (författare)
Charité Universitätsmedizin Berlin, Institute of Public Health, Berlin, Germany.,Charité - University Medicine Berlin
Eriksen, Björn O. (författare)
Metabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsö, Norway.
Dalton, R Neil (författare)
The Wellchild Laboratory, Evelina London Children's Hospital, London, United Kingdom.,Evelina London Children's Healthcare
Dubourg, Laurence (författare)
Néphrologie, Dialyse, Hypertension et Exploration Fonctionnelle Rénale, Hôpital Edouard Herriot, Hospices Civils de Lyon, France.,Claude Bernard University Lyon 1
Gaillard, Francois (författare)
Renal Transplantation Department, Assistance Publique-Hôpitaux de Paris (AP-HP), France,Hôpital Edouard Herriot
Garrouste, Cyril (författare)
Department of Nephrology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.
Grubb, Anders (författare)
Lund University,Lunds universitet,Cystatin C, njursjukdom, amyloidos och antibiotika,Forskargrupper vid Lunds universitet,Cystatin C, renal disease, amyloidosis and antibiotics,Lund University Research Groups,Skåne University Hospital
Jacquemont, Lola (författare)
Renal Transplantation Department, CHU Nantes, Nantes University, Nantes, France.,University of Nantes
Hansson, Magnus (författare)
Karolinska Institute,Karolinska Institutet,Function area Clinical Chemistry, Karolinska University Laboratory, Karolinska University Hospital Huddinge and Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.
Kamar, Nassim (författare)
Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, INSERM U1043, IFR -BMT, University Paul Sabatier, Toulouse, France.,Rangueil Hospital
Lamb, Edmund J. (författare)
Clinical Biochemistry, East Kent Hospitals University NHS Foundation Trust, Canterbury, United Kingdom.
Legendre, Christophe (författare)
Hôpital Necker, AP-HP & Université Paris Descartes, Paris, France.,Necker-Enfants Malades Hospital
Littmann, Karin (författare)
Karolinska Institute,Karolinska Institutet,Department of Medicine Huddinge (MedH), Karolinska Institute, Huddinge, Sweden.
Mariat, Christophe (författare)
Service de Néphrologie, Dialyse et Transplantation Rénale, Hôpital Nord, CHU de Saint-Etienne, France.
Melsom, Toralf (författare)
Metabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsö, Norway,Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, Hôpital Michallon, CHU Grenoble-Alpes, France.
Rostaing, Lionel (författare)
Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, Hôpital Michallon, CHU Grenoble-Alpes, France,Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.,Grenoble University Hospital
Rule, Andrew D. (författare)
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.,Mayo Clinic Minnesota
Schaeffner, Elke (författare)
Charité Universitätsmedizin Berlin, Institute of Public Health, Berlin, Germany,Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.,Charité - University Medicine Berlin
Sundin, Per-Ola, 1971- (författare)
Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Geriatrics, School of Medical Sciences, Örebro University, Örebro, Sweden.
Berg, Ulla (författare)
Karolinska Institutet,Department of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Åsling-Monemi, Kajsa (författare)
Department of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Selistre, Luciano (författare)
Mestrado em Ciências da Saúde -Universidade Caxias do Sul Foundation CAPES, Brazil.,University of Caxias do Sul
Åkesson, Anna (författare)
Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,EPI@LUND,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups
Larsson, Anders (författare)
Uppsala universitet,Klinisk kemi,Academic Medical Center of University of Amsterdam (AMC)
Bökenkamp, Arend (författare)
Uppsala University
Pottel, Hans (författare)
Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.,Catholic University of Leuven
Nyman, Ulf (författare)
Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Department of Translational Medicine,Faculty of Medicine,Radiology Diagnostics, Malmö,Lund University Research Groups
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 (creator_code:org_t)
2021-12-03
2022
Engelska.
Ingår i: British Journal of Clinical Pharmacology. - : Wiley-Blackwell Publishing Inc.. - 0306-5251 .- 1365-2125. ; 88:5, s. 2118-2127
Relaterad länk:
http://dx.doi.org/10...
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https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
https://urn.kb.se/re...
https://lup.lub.lu.s...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • AIM: The Cockcroft-Gault (CG) creatinine-based equation is still used to estimate glomerular filtration rate (eGFR) for drug dosage adjustment. Incorrect eGFR may lead to hazardous over- or underdosing METHODS: In a cross-sectional analysis, CG was validated against measured GFR (mGFR) in 14,804 participants and compared with the Modification-of-Diet-in-Renal-Diseases (MDRD), Chronic-Kidney-Disease-Epidemiology (CKD-EPI), Lund-Malmö-Revised (LMR), and European-Kidney-Function-Consortium (EKFC) equations. Validation focused on bias, imprecision, and accuracy (percentage of estimates within ±30% of mGFR, P30), overall and stratified for mGFR, age, and body mass index at mGFR <60 mL/min, as well as classification in mGFR stages.RESULTS: The CG equation performed worse than the other equations, overall and in mGFR, age and BMI subgroups in terms of bias (systematic overestimation), imprecision and accuracy except for patients ≥65 years where bias and P30 were similar to MDRD and CKD-EPI, but worse than LMR and EKFC. In subjects with mGFR<60 mL/min and at BMI [18.5-25[kg/m2 , all equations performed similarly and for BMI<18.5kg/m2 CG and LMR had the best results though all equations had poor P30-accuracy. At BMI≥25kg/m2 the bias of the CG increased with increasing BMI (+17.2mL/min at BMI≥40kg/m2 ). The four more recent equations also classified mGFR stages better than CG.CONCLUSIONS: The CG equation showed poor ability to estimate GFR overall and in analyses stratified for GFR, age, and BMI. CG was inferior to correctly classify the patients in the mGFR staging compared to more recent creatinine-based equations.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)

Nyckelord

Chronic kidney disease
drug adjustment
glomerular filtration rate
chronic kidney disease
drug adjustment
glomerular filtration rate

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