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Adverse Childhood E...
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Baldwin, Jessie R.Department of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, UK; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
(författare)
Adverse Childhood Experiences and Mental Health : A Genetically Informed Study
- Artikel/kapitelEngelska2021
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Springer,2021
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-95357
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-95357URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:vet swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Children exposed to adverse childhood experiences (ACEs) have an elevated risk of mental health problems, but it is unclear whether these associations reflect genetic confounding. We tested (1) whether children with genetic liability to psychopathology are more likely to experience ACEs, and (2) the extent to which the associations between ACEs and mental health are genetically confounded. Par-ticipants were 6411 children from the Avon Longitudinal Study of Parents and Children (ALSPAC). ACEs (including maltreatment, domestic violence, and parental psychopathology, substance abuse, criminality, and separation) were prospectively measured through parent reports at multiple assessments between birth and age 9. Internalizing and externalizing problems at age 9 were assessed through parent reports on the Development and Wellbeing Assessment. We derived polygenic scores for a range of psychiatric disorders. Children with greater genetic liability to psychopathology had a small elevation in risk of ACEs (pooled odds ratio = 1.05, 95% CI 1.01–1.09). Measured polygenic scores accounted for a very small proportion of the associations between ACEs with internalizing problems (pooled average across ACEs = 3.6%) and externalizing problems (pooled average = 4.8%). However, latent polygenic scores capturing SNP heritability in mental health outcomes explained a larger proportion of the associations between ACEs with internalizing problems (pooled average = 63%) and externalizing problems (pooled average = 17%). Risk of mental health problems in children exposed to ACEs is partly, but not completely driven by pre-existing genetic liability to psychopathology. Assuming the absence of nongenetic confounding, these findings are consistent with a partly causal effect of ACEs on mental health.
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Sallis, Hannah M.MRC Integrative Epidemiology Unit at the University of Bristol, Bristol Medical School, University of Bristol, Bristol, UK; School of Psychological Science, University of Bristol, Bristol, UK; NIHR Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK; Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
(författare)
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Schoeler, TabeaDepartment of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, UK
(författare)
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Taylor, Mark J.Medical SchoolDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
(författare)
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Kwong, Alex S. F.MRC Integrative Epidemiology Unit at the University of Bristol, Bristol Medical School, University of Bristol, Bristol, UK; stitutet, Nobels va ̈Division of Psychiatry, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK
(författare)
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Howe, Laura D.MRC Integrative Epidemiology Unit at the University of Bristol, Bristol Medical School, University of Bristol, Bristol, UK
(författare)
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Danese, AndreaSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK; Department of Child & Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom; National and Specialist CAMHS Trauma, Anxiety, and Depression Clinic, South London and Maudsley NHS Foundation Trust, London, UK
(författare)
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McCrory, EamonDepartment of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, UK; Anna Freud National Centre for Children and Families, London, UK
(författare)
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Rijsdijk, FruhlingSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
(författare)
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Tielbeek, Jorim J.CNCR, Amsterdam Neuroscience Campus, VU University, Amsterdam, The Netherlands
(författare)
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Barkhuizen, WikusDepartment of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, UK
(författare)
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Larsson, Henrik,1975-Örebro universitet,Institutionen för medicinska vetenskaper,Bristol Medical School, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)hiln
(författare)
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Lundström, SebastianGillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; Centre for Ethics, Law and Mental Health (CELAM), Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
(författare)
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Karlsson, RobertBristol Medical School, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
(författare)
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Lichtenstein, PaulBristol Medical School, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
(författare)
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Munafo, MarcusMRC Integrative Epidemiology Unit at the University of Bristol, Bristol Medical School, University of Bristol, Bristol, UK; School of Psychological Science, University of Bristol, Bristol, UK; NIHR Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK
(författare)
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Pingault, Jean-BaptisteDepartment of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, UK; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
(författare)
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Department of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, UK; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UKMRC Integrative Epidemiology Unit at the University of Bristol, Bristol Medical School, University of Bristol, Bristol, UK; School of Psychological Science, University of Bristol, Bristol, UK; NIHR Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK; Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Behavior Genetics: Springer51:6, s. 691-6920001-82441573-3297
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Baldwin, Jessie ...
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Sallis, Hannah M ...
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Schoeler, Tabea
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Taylor, Mark J.
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Kwong, Alex S. F ...
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Howe, Laura D.
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visa fler...
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Danese, Andrea
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McCrory, Eamon
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Rijsdijk, Fruhli ...
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Tielbeek, Jorim ...
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Barkhuizen, Wiku ...
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Larsson, Henrik, ...
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Lundström, Sebas ...
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Karlsson, Robert
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Lichtenstein, Pa ...
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Munafo, Marcus
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Pingault, Jean-B ...
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