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Serial NIRS-IVUS As...
Serial NIRS-IVUS Assessment of Changes in Coronary Lumen Area During 2-Year Follow-Up : Insights From the PROSPECT ABSORB Trial
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- Matsumura, Mitsuaki (författare)
- Cardiovascular Research Foundation, New York, New York, USA
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- Maehara, Akiko (författare)
- Cardiovascular Research Foundation, New York, New York, USA
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- Mintz, Gary (författare)
- Cardiovascular Research Foundation, Washington, DC, USA
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- Ben-Yehuda, Ori (författare)
- Cardiovascular Research Foundation, Columbia University Medical Center, New York, New York, USA
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- Maeng, Michael (författare)
- Aarhus University Hospital, Aarhus, Denmark
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- Kjoller-Hansen, Lars (författare)
- Interventional Cardiologist, Roskilde, Denmark
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- Engstroem, Thomas (författare)
- The Heart Centre, University of Copenhagen, Copenhagen, Denmark
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- Fröbert, Ole, 1964- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Persson, Jonas (författare)
- Danderyd University Hospital, Stockholm, Sweden
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- Wiseth, Rune (författare)
- STOH, Trondheim, Norway
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- Larsen, Alf Inge (författare)
- Stavanger University Hospital, Stavanger, Norway
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- Jensen, Lisette Okkels (författare)
- Odense University Hospital, Odense, Denmark
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- Nordrehaug, Jan Erik (författare)
- University of Bergen, Department of Clinical Science, Bergen, Norway
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- Bleie, Oyvind (författare)
- Haukeland University Hospital, Bergen, Norway
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- Omerovic, Elmir (författare)
- Department of Cardiology, Gothenburg, Sweden
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- Zhou, Zhipeng (författare)
- Cardiovascular Research Foundation, New York, New York, USA
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- Held, Claes (författare)
- Uppsala Universitet, Uppsala, Sweden
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- James, Stefan (författare)
- Uppsala University, Uppsala, Sweden
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- Ali, Ziad (författare)
- Saint Francis Heart Center, Roslyn, New York, USA
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- Erlinge, David (författare)
- Skane University Hospital, Lund, Sweden
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- Stone, Gregg (författare)
- Cardiovascular Research Foundation, New York, New York, USA
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Journal of the American College of Cardiology. - : Elsevier. - 0735-1097 .- 1558-3597. ; 78:19 Suppl., s. B35-B36
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
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- Background: In PROSPECT II, 182 patients with plaque burden (PB) ≥ 65% were randomized to bioresorbable vascular scaffold (BVS) + guideline-directed medical therapy (GDMT) versus GDMT alone. Protocol-directed 3-vessel near-infrared spectroscopy (NIRS)-IVUS was repeated at 25 months.Methods: Excluding lesions treated by BVS, paired (baseline and follow-up) NIRS-IVUS was available in 626 nonculprit lesions in 165 patients. Follow-up minimum lumen area (MLA) and the corresponding baseline sites were measured: rapid lesion progression (RLP) was a ≥ 0.5 mm2 decrease of MLA, and rapid lesion regression (RLR) was a ≥ 0.5 mm2 increase of MLA.Results: RLP occurred in 34.5%, RLR occurred in 15.5%, and 49.8% had “no change.” The % change in vessel area correlated with the % change of plaque area (r = 0.81, P < 0.001), demonstrating vessel remodeling (Figure 1). At baseline, the RLP lesions had larger plaque areas, longer lesions, and higher prevalence of lipid-rich plaque (maxLCBI4mm ≥ 324.7). During follow-up, 80.2% of RLP lesions had negative remodeling irrespective of the change in plaque area, whereas 76.3% of RLR lesions had a decrease in plaque area irrespective of negative or positive remodeling. In lesions without change in lumen area, there were compensatory changes in plaque and vessel areas.Conclusion: In stabilized patients post-MI treated with GDMT, half of untreated non–flow- limiting lesions had significant lumen changes at 25 months, with RLP twice as frequent as RLR. The predominant mechanism of RLP was negative vessel remodeling whereas the predominant mechanism of RLR was reduction in plaque area.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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Matsumura, Mitsu ...
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Maehara, Akiko
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Mintz, Gary
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Ben-Yehuda, Ori
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Maeng, Michael
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Kjoller-Hansen, ...
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visa fler...
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Engstroem, Thoma ...
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Fröbert, Ole, 19 ...
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Persson, Jonas
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Wiseth, Rune
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Larsen, Alf Inge
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Jensen, Lisette ...
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Nordrehaug, Jan ...
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Bleie, Oyvind
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Omerovic, Elmir
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Zhou, Zhipeng
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Held, Claes
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James, Stefan
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Ali, Ziad
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Erlinge, David
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Stone, Gregg
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