The Association Between Beta-Blocker Therapy and Mortality in Hip Fracture Patients

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: id:"swepub:oai:DiVA.org:oru-95781" > The Association Bet...

1 av 1
Föregående post
Nästa post
Till träfflistan

Mohammad Ismail, Ahmad,1993-Örebro universitet,Institutionen för medicinska vetenskaper (författare)

The Association Between Beta-Blocker Therapy and Mortality in Hip Fracture Patients

BokEngelska2022

Förlag, utgivningsår, omfång ...

Örebro :Örebro University,2022
69 s.
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:oru-95781
ISBN:9789175294179
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-95781URI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:vet swepub-contenttype
Ämneskategori:dok swepub-publicationtype

Serie

Örebro Studies in Medicine,1652-4063 ;252

Anmärkningar

Hip fractures have been a major concern within the healthcare systems for many years. National efforts have been done to improve the overall outcomes during the last decades. Despite this, the mortality rates one year after hip fracture surgery are as high as 27% and have remained high the past 15 years. Patients that suffer from hip fractures are often elderly and have several comorbidities. The orthopaedic trauma and subsequent emergency surgery impose an activation of the sympathetic nervous system mediated through the release of catecholamines. This causes a hyper-adrenergic state, which can be harmful if prolonged, or if the patient already has a strain caused by comorbidities forgoing the injury, especially on the cardiovascular system. This gave rise to the thought of blocking the adrenergic receptor activation in hip fracture patients as an effort to reduce the mortality rates.Papers I and II investigates the association between beta-blocker therapy and short-term mortality in hip fracture patients. In Paper I, (n=2443) patients operated in Orebro County between 2013 to 2017 were extracted from The National Quality Register for Hip Fractures (Rikshöft), to enable a more detailed review of the medical journals. The patients were divided into a betablocker cohort and a beta-blocker naive cohort. Results showed an 18% reduction in the risk of postoperative mortality within 90 days of surgery. In Paper II, all adults operated for traumatic hip fractures in Sweden between 2008 to 2017 were extracted from The National Quality Register for Hip Fractures and then cross-referenced with data from registers of The National Board of Health and Welfare. This resulted in a total of 134,915 patients eligible for analysis. The results demonstrated a 72% risk reduction in postoperative mortality within 30 days of surgery in the cohort with ongoing beta-blocker therapy.Paper III explored if the effect seen in Paper I-II remains up to one year using the same database as Paper II. The results demonstrated that the association between beta-blocker therapy and reduction in the risk of mortality,extending up to one year postoperatively, with the main effect seen during the first postoperative period.Paper IV investigates the interaction between the Revised Cardiac Risk Index and beta-blocker therapy related to 30-day post-operative mortality. This study concluded that all geriatric hip fracture patients could benefit from beta-blockers, but a more pronounced effect was seen in those with cardiac risk factors.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
Trauma
Hip Fracture
Beta-Blocker
Hyperadrenergic State
Stress
Mortality

Biuppslag (personer, institutioner, konferenser, titlar ...)

Mohseni, Shahin,biträdande professor,1978-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län(Swepub:oru)snmi (preses)
Ahl, Rebecka,PhD,1987-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)raal (preses)
Wretenberg, Per,professor,1963-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)pewg (preses)
Borg, Tomas,PhD,1963-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län(Swepub:oru)tbg (preses)
Rosengren, Björn,professorSkånes universitetssjukhus, Lunds universitet, Lund (opponent)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Internetlänk

Hitta via bibliotek

The Association Between Beta-Blocker Therapy and Mortality in Hip Fracture Patie... (Sök publikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Av författaren/redakt...: Mohammad Ismail, ...; Mohseni, Shahin, ...; Ahl, Rebecka, Ph ...; Wretenberg, Per, ...; Borg, Tomas, PhD ...; Rosengren, Björn ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kirurgi

Delar i serien: Örebro Studies i ...

Av lärosätet: Örebro universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se