SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(de la Cruz Lorena Fernández)
 

Search: WFRF:(de la Cruz Lorena Fernández) > (2020-2024) > Associations of par...

  • Li, YuchenMental Health Center, West China Hospital of Sichuan University, Chengdu, China; West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (author)

Associations of parental and perinatal factors with subsequent risk of stress-related disorders : a nationwide cohort study with sibling comparison

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-01-01
  • Springer Nature,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-96401
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-96401URI
  • https://doi.org/10.1038/s41380-021-01406-5DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148445102URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies:China Scholarship CouncilGrant of Excellence, Icelandic Research Fund 163362-051 Swedish Research Council through the Swedish Initiative for Research on Microdata in the Social And Medical Sciences (SIMSAM) framework 340-2013-5867 
  • Little is known about the contribution of pregnancy-related parental and perinatal factors to the development of stress-related disorders. We aimed to investigate whether parental/perinatal adversities entail higher risks of stress-related disorders in the offspring, later in life, by accounting for genetic and early environmental factors. Based on the nationwide Swedish registers, we conducted a population-based cohort study of 3,435,747 singleton births (of which 2,554,235 were full siblings), born 1973-2008 and survived through the age of 5 years. Using both population- and sibling designs, we employed Cox regression to assess the association between parental and perinatal factors with subsequent risk of stress-related disorders. We identified 55,511 individuals diagnosed with stress-related disorders in the population analysis and 37,433 in the sibling analysis. In the population-based analysis we observed increased risks of stress-related disorders among offspring of maternal/paternal age <25, single mothers, parity >= 4, mothers with BMI >= 25 or maternal smoking in early pregnancy, gestational diabetes, and offspring born moderately preterm (GA 32-36 weeks), or small-for-gestational-age. These associations were significantly attenuated toward null in the sibling analysis. Cesarean-section was weakly associated with offspring stress-related disorders in population [hazard ratio (HR) 1.09, 95% confidence interval (CI) 1.06-1.12] and sibling analyses (HR 1.10, 95% CI 1.02-1.20). Our findings suggest that most of the observed associations between parental and perinatal factors and risk of stress-related disorders in the population analysis are driven by shared familial environment or genetics, and underscore the importance of family designs in epidemiological studies on the etiology of psychiatric disorders.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sjölander, ArvidKarolinska Institutet (author)
  • Song, HuanWest China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China; Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland (author)
  • Cnattingius, SvenKarolinska Institutet (author)
  • Fang, FangKarolinska Institutet (author)
  • Yang, QianDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (author)
  • de la Cruz, Lorena FernándezKarolinska Institutet (author)
  • Mataix-Cols, DavidKarolinska Institutet (author)
  • Brander, GustafDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden (author)
  • Li, JiongDepartment of Clinical Medicine-Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark (author)
  • Zhang, WeiMental Health Center, West China Hospital of Sichuan University, Chengdu, China; West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China (author)
  • Fall, Katja,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden(Swepub:oru)kafl (author)
  • D'Onofrio, Brian M.Karolinska Institutet (author)
  • Almqvist, CatarinaKarolinska Institutet (author)
  • Lichtenstein, PaulKarolinska Institutet (author)
  • Valdimarsdottir, Unnur A.Karolinska Institutet (author)
  • Lu, DonghaoKarolinska Institutet (author)
  • Karolinska InstitutetMental Health Center, West China Hospital of Sichuan University, Chengdu, China; West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (creator_code:org_t)

Related titles

  • In:Molecular Psychiatry: Springer Nature27, s. 1712-17191359-41841476-5578

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view