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Analysis of the SYS...
Analysis of the SYSDIET Healthy Nordic Diet randomized trial based on metabolic profiling reveal beneficial effects on glucose metabolism and blood lipids
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- Gürdeniz, Gözde (författare)
- Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark; Department of Food Science, University of Copenhagen, Frederiksberg, Denmark,Univ Copenhagen, Dept Nutr Exercise & Sports, Frederiksberg, Denmark.;Univ Copenhagen, Dept Food Sci, Frederiksberg, Denmark
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- Uusitupa, Matti (författare)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland
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- Hermansen, Kjeld (författare)
- Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Dept Endocrinol & Internal Med, Aarhus, Denmark
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- Savolainen, Markku J. (författare)
- Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland,Univ Oulu, Inst Clin Med, Dept Internal Med, Oulu, Finland
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- Schwab, Ursula (författare)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Department of Medicine, Endocrinology and Clinical Nutrition, Kuopio University Hospital, Kuopio, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.;Kuopio Univ Hosp, Dept Med Endocrinol & Clin Nutr, Kuopio, Finland
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- Kolehmainen, Marjukka (författare)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland
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- Brader, Lea (författare)
- Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Dept Endocrinol & Internal Med, Aarhus, Denmark
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- Cloetens, Lieselotte (författare)
- Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Herzig, Karl-Heinz (författare)
- Institute of Biomedicine and Biocenter of Oulu, University of Oulu, Finland; Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland,Univ Oulu, Inst Biomed, Oulu, Finland.;Univ Oulu, Bioctr Oulu, Oulu, Finland.;Kuopio Univ Hosp, Dept Psychiat, Kuopio, Finland
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- Hukkanen, Janne (författare)
- Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland,Univ Oulu, Inst Clin Med, Dept Internal Med, Oulu, Finland
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- Rosqvist, Fredrik, 1985- (författare)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap
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- Ulven, Stine Marie (författare)
- Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway,Univ Oslo, Inst Basic Med Sci, Dept Nutr, Oslo, Norway
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- Gunnarsdóttir, Ingibjörg (författare)
- Unit for Nutrition Research, Faculty of Food Science and Nutrition, University of Iceland, Reykjavík, Iceland; Unit for Nutrition Research, Landspitali National University Hospital, Reykjavik, Iceland,Univ Iceland, Fac Food Sci & Nutr, Unit Nutr Res, Reykjavik, Iceland.;Landspitali Natl Univ Hosp, Unit Nutr Res, Reykjavik, Iceland
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- Thorsdottir, Inga (författare)
- Unit for Nutrition Research, Faculty of Food Science and Nutrition, University of Iceland, Reykjavík, Iceland; Unit for Nutrition Research, Landspitali National University Hospital, Reykjavik, Iceland,Univ Iceland, Fac Food Sci & Nutr, Unit Nutr Res, Reykjavik, Iceland.;Landspitali Natl Univ Hosp, Unit Nutr Res, Reykjavik, Iceland
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- Oresic, Matej, 1967- (författare)
- Turku Center for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland; VTT Technical Research Centre of Finland, Espoo, Finland,Univ Turku, Turku Ctr Biotechnol, Turku, Finland.;Abo Akad Univ, Turku, Finland.;VTT Tech Res Ctr Finland, Espoo, Finland
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- Poutanen, Kaisa S. (författare)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; VTT Technical Research Centre of Finland, Espoo, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.;VTT Tech Res Ctr Finland, Espoo, Finland
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- Risérus, Ulf, 1967- (författare)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap
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- Åkesson, Björn (författare)
- Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Skåne University Hospital
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- Dragsted, Lars Ove (författare)
- Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg,Univ Copenhagen, Dept Nutr Exercise & Sports, Frederiksberg, Denmark
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Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark; Department of Food Science, University of Copenhagen, Frederiksberg, Denmark Univ Copenhagen, Dept Nutr Exercise & Sports, Frederiksberg, Denmark;Univ Copenhagen, Dept Food Sci, Frederiksberg, Denmark (creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Clinical Nutrition. - : Elsevier. - 0261-5614 .- 1532-1983. ; 41:2, s. 441-451
- Relaterad länk:
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https://doi.org/10.1...
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http://www.clinicaln...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND & AIMS: Intake assessment in multicenter trials is challenging, yet important for accurate outcome evaluation. The present study aimed to characterize a multicenter randomized controlled trial with a healthy Nordic diet (HND) compared to a Control diet (CD) by plasma and urine metabolic profiles and to associate them with cardiometabolic markers.METHODS: During 18-24 weeks of intervention, 200 participants with metabolic syndrome were advised at six centres to eat either HND (e.g. whole-grain products, berries, rapeseed oil, fish and low-fat dairy) or CD while being weight stable. Of these 166/159 completers delivered blood/urine samples. Metabolic profiles of fasting plasma and 24 h pooled urine were analysed to identify characteristic diet-related patterns. Principal components analysis (PCA) scores (i.e. PC1 and PC2 scores) were used to test their combined effect on blood glucose response (primary endpoint), serum lipoproteins, triglycerides, and inflammatory markers.RESULTS: The profiles distinguished HND and CD with AUC of 0.96 ± 0.03 and 0.93 ± 0.02 for plasma and urine, respectively, with limited heterogeneity between centers, reflecting markers of key foods. Markers of fish, whole grain and polyunsaturated lipids characterized HND, while CD was reflected by lipids containing palmitoleic acid. The PC1 scores of plasma metabolites characterizing the intervention is associated with HDL (β = 0.05; 95% CI: 0.02, 0.08; P = 0.001) and triglycerides (β = -0.06; 95% CI: -0.09, -0.03; P < 0.001). PC2 scores were related with glucose metabolism (2 h Glucose, β = 0.1; 95% CI: 0.05, 0.15; P < 0.001), LDL (β = 0.06; 95% CI: 0.01, 0.1; P = 0.02) and triglycerides (β = 0.11; 95% CI: 0.06, 0.15; P < 0.001). For urine, the scores were related with LDL cholesterol.CONCLUSIONS: Plasma and urine metabolite profiles from SYSDIET reflected good compliance with dietary recommendations across the region. The scores of metabolites characterizing the diets associated with outcomes related with cardio-metabolic risk. Our analysis therefore offers a novel way to approach a per protocol analysis with a balanced compliance assessment in larger multicentre dietary trials. The study was registered at clinicaltrials.gov with NCT00992641.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Glucose and lipid metabolism
- Healthy Nordic diet
- LC–MS metabolomics
- Plasma metabolite scores
- Randomized controlled trial
- Glucose and lipid metabolism
- Healthy Nordic diet
- LC–MS metabolomics
- Plasma metabolite scores
- Randomized controlled trial
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Gürdeniz, Gözde
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Uusitupa, Matti
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Hermansen, Kjeld
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Savolainen, Mark ...
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Schwab, Ursula
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Kolehmainen, Mar ...
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Brader, Lea
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Cloetens, Liesel ...
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Herzig, Karl-Hei ...
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Hukkanen, Janne
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Rosqvist, Fredri ...
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Ulven, Stine Mar ...
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Gunnarsdóttir, I ...
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Thorsdottir, Ing ...
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Oresic, Matej, 1 ...
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Poutanen, Kaisa ...
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Risérus, Ulf, 19 ...
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Åkesson, Björn
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Dragsted, Lars O ...
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Clinical Nutriti ...
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Örebro universitet
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