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Sökning: WFRF:(Andrén Ove) > (2020-2024) > Prognostic Utility ...

  • Zelic, RenataKarolinska Institutet (författare)

Prognostic Utility of the Gleason Grading System Revisions and Histopathological Factors Beyond Gleason Grade.

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Dove Medical Press Ltd.2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-96822
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-96822URI
  • https://doi.org/10.2147/CLEP.S339140DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148603494URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:Strategic Research Programme in Epidemiology at Karolinska InstitutetStrategic Research Programme in Cancer at Karolinska InstitutetSardinian Regional Authority (the DIFRA Project)
  • Background: The International Society of Urological Pathology (ISUP) revised the Gleason system in 2005 and 2014. The impact of these changes on prostate cancer (PCa) prognostication remains unclear.Objective: To evaluate if the ISUP 2014 Gleason score (GS) predicts PCa death better than the pre-2005 GS, and if additional histopathological information can further improve PCa death prediction.Patients and Methods: We conducted a case-control study nested among men in the National Prostate Cancer Register of Sweden diagnosed with non-metastatic PCa 1998-2015. We included 369 men who died from PCa (cases) and 369 men who did not (controls). Two uro-pathologists centrally re-reviewed biopsy ISUP 2014 Gleason grading, poorly formed glands, cribriform pattern, comedonecrosis, perineural invasion, intraductal, ductal and mucinous carcinoma, percentage Gleason 4, inflammation, high-grade prostatic intraepithelial neoplasia (HGPIN) and post-atrophic hyperplasia. Pre-2005 GS was back-transformed using i) information on cribriform pattern and/or poorly formed glands and ii) the diagnostic GS from the registry. Models were developed using Firth logistic regression and compared in terms of discrimination (AUC).Results: The ISUP 2014 GS (AUC = 0.808) performed better than the pre-2005 GS when back-transformed using only cribriform pattern (AUC = 0.785) or both cribriform and poorly formed glands (AUC = 0.792), but not when back-transformed using only poorly formed glands (AUC = 0.800). Similarly, the ISUP 2014 GS performed better than the diagnostic GS (AUC = 0.808 vs 0.781). Comedonecrosis (AUC = 0.811), HGPIN (AUC = 0.810) and number of cores with ≥50% cancer (AUC = 0.810) predicted PCa death independently of the ISUP 2014 GS.Conclusion: The Gleason Grading revisions have improved PCa death prediction, likely due to classifying cribriform patterns, rather than poorly formed glands, as Gleason 4. Comedonecrosis, HGPIN and number of cores with ≥50% cancer further improve PCa death discrimination slightly.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Giunchi, FrancescaPathology Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (författare)
  • Fridfeldt, JonnaDepartment of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (författare)
  • Carlsson, Jessica,1984-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Urology(Swepub:oru)jccn (författare)
  • Davidsson, Sabina,1972-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Urology(Swepub:oru)sdn (författare)
  • Lianas, LucaData-Intensive Computing Division, Center for Advanced Studies, Research and Development in Sardinia (CRS4), Pula, Italy (författare)
  • Mascia, CeciliaData-Intensive Computing Division, Center for Advanced Studies, Research and Development in Sardinia (CRS4), Pula, Italy (författare)
  • Zugna, DanielaCancer Epidemiology Unit, Department of Medical Sciences, University of Turin, and CPO-Piemonte, Turin, Italy (författare)
  • Molinaro, LucaDivision of Pathology, A.O. Città della Salute e della Scienza Hospital, Turin, Italy (författare)
  • Vincent, Per HenrikKarolinska Institutet (författare)
  • Zanetti, GianluigiData-Intensive Computing Division, Center for Advanced Studies, Research and Development in Sardinia (CRS4), Pula, Italy (författare)
  • Andrén, Ove,1963-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology(Swepub:oru)oan (författare)
  • Richiardi, LorenzoCancer Epidemiology Unit, Department of Medical Sciences, University of Turin, and CPO-Piemonte, Turin, Italy (författare)
  • Akre, OlofKarolinska Institutet (författare)
  • Fiorentino, MichelangeloPathology Service, Maggiore Hospital, University of Bologna, Bologna, Italy (författare)
  • Pettersson, AndreasKarolinska Institutet (författare)
  • Karolinska InstitutetPathology Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Clinical Epidemiology: Dove Medical Press Ltd.14, s. 59-701179-1349

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