Postoperative non-steroidal anti-inflammatory drug use and oncological outcomes of rectal cancer

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Grahn, OskarUmeå University,Umeå universitet,Kirurgi (författare)

Postoperative non-steroidal anti-inflammatory drug use and oncological outcomes of rectal cancer

Artikel/kapitelEngelska2021

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2021-02-15
Oxford University Press (OUP),2021

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LIBRIS-ID:oai:gup.ub.gu.se/305413
https://gup.ub.gu.se/publication/305413URI
https://doi.org/10.1093/bjsopen/zraa050DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-181655URI
https://lup.lub.lu.se/record/f47f9848-f46f-48e3-955c-c0abe85400fcURI

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Språk:engelska

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Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are known to suppress the inflammatory response after surgery and are often used for pain control. This study aimed to investigate NSAID use after radical surgical resection for rectal cancer and long-term oncological outcomes. Methods: A cohort of patients who underwent anterior resection for rectal cancer between 2007 and 2013 in 15 hospitals in Sweden was investigated retrospectively. Data were obtained from the Swedish Colorectal Cancer Registry and medical records; follow-up was undertaken until July 2019. Patients who received NSAID treatment for at least 2 days after surgery were compared with controls who did not, and the primary outcome was recurrence-free survival. Cox regression modelling with confounder adjustment, propensity score matching, and an instrumental variables approach were used; missing data were handled by multiple imputation. Results: The cohort included 1341 patients, 362 (27.0 per cent) of whom received NSAIDs after operation. In analyses using conventional regression and propensity score matching, there was no significant association between postoperative NSAID use and recurrence-free survival (adjusted hazard ratio (HR) 1.02, 0.79 to 1.33). The instrumental variables approach, including individual hospital as the instrumental variable and clinicopathological variables as co-variables, suggested a potential improvement in the NSAID group (HR 0.61, 0.38 to 0.99). Conclusion: Conventional modelling did not demonstrate an association between postoperative NSAID use and recurrence-free survival in patients with rectal cancer, although an instrumental variables approach suggested a potential benefit.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
anastomotic leakage
colorectal-cancer
surgery
risk
Surgery

Biuppslag (personer, institutioner, konferenser, titlar ...)

Lundin, Mathias,1971-Lund University,Lunds universitet,Umeå University,Umeå universitet,Statistik,Kirurgi,Department of Surgery, Skåne University Hospital, Malmö, Lund University, Lund, Sweden,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)med-msl (författare)
Lydrup, M. L. (författare)
Angenete, Eva,1972Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Department of Surgery, Institute of Clinical Sciences, Scandinavian Surgical Outcomes Research Group, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Department of Surgery, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden(Swepub:gu)xangee (författare)
Rutegård, Martin,1982-Umeå University,Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Kirurgi(Swepub:umu)maru0039 (författare)
Umeå universitetKirurgi (creator_code:org_t)

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Av författaren/redakt...: Grahn, Oskar; Lundin, Mathias, ...; Lydrup, M. L.; Angenete, Eva, 1 ...; Rutegård, Martin ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kirurgi

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Av lärosätet: Göteborgs universitet; Umeå universitet; Lunds universitet

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