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Salivary glands abn...
Salivary glands abnormalities in oculo-auriculo-vertebral spectrum
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- Brotto, Davide (författare)
- Department of Neurosciences, University of Padova, Padova, Italy
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- Manara, Renzo (författare)
- Neuroradiology, Sezione di Neuroscienze, University of Salerno, Salerno, Italy
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- Vio, Stefania (författare)
- Radiology Unit, Azienda Ospedaliera di Padova, Padova, Italy
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- Ghiselli, Sara (författare)
- Department of Neurosciences, University of Padova, Padova, Italy
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- Cantone, Elena (författare)
- ENT section, Neurosciences Department, Federico II, Naples, Italy
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- Mardari, Rodica (författare)
- Neuroradiology, University Hospital of Padova, Padova, Italy
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- Toldo, Irene (författare)
- Pediatric Neurology Unit, Department of Woman's and Child's Health, University of Padova, Padova, Italy
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- Stritoni, Valentina (författare)
- TIPED, Department of Pediatrics, University of Padova, Padova, Italy
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- Castiglione, Alessandro, 1976- (författare)
- Department of Neurosciences, University of Padova, Padova, Italy
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- Lovo, Elisa (författare)
- Department of Neurosciences, University of Padova, Padova, Italy
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- Trevisi, Patrizia (författare)
- Department of Neurosciences, University of Padova, Padova, Italy
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- Bovo, Roberto (författare)
- Department of Neurosciences, University of Padova, Padova, Italy
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- Martini, Alessandro (författare)
- Department of Neurosciences, University of Padova, Padova, Italy
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(creator_code:org_t)
- 2017-05-22
- 2018
- Engelska.
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Ingår i: Clinical Oral Investigations. - Berlin, Germany : Springer. - 1432-6981 .- 1436-3771. ; 22:1, s. 395-400
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Feeding and swallowing impairment are present in up to 80% of oculo-auriculo-vertebral spectrum (OAVS) patients. Salivary gland abnormalities have been reported in OAVS patients but their rate, features, and relationship with phenotype severity have yet to be defined.Material and methods: Parotid and submandibular salivary gland hypo/aplasia was evaluated on head MRI of 25 OAVS patients (16 with severe phenotype, Goldenhar syndrome) and 11 controls.Results: All controls disclosed normal salivary glands. Abnormal parotid glands were found exclusively ipsilateral to facial microsomia in 21/25 OAVS patients (84%, aplasia in six patients) and showed no association with phenotype severity (14/16 patients with Goldenhar phenotype vs 7/9 patients with milder phenotype, p = 0.6). Submandibular salivary gland hypoplasia was detected in six OAVS patients, all with concomitant ipsilateral severe involvement of the parotid gland (p < 0.001). Submandibular salivary gland hypoplasia was associated to Goldenhar phenotype (p < 0.05). Parotid gland abnormalities were associated with ipsilateral fifth (p < 0.001) and seventh cranial nerve (p = 0.001) abnormalities. No association was found between parotid gland anomaly and ipsilateral internal carotid artery, inner ear, brain, eye, or spine abnormalities (p > 0.6).Conclusions: Salivary gland abnormalities are strikingly common in OAVS. Their detection might help the management of OAVS-associated swallowing and feeding impairment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Goldenhar syndrome
- Oculo-auriculo-vertebral spectrum
- Parotid gland
- Submandibular gland
- MRI
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Brotto, Davide
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Manara, Renzo
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Vio, Stefania
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Ghiselli, Sara
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Cantone, Elena
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Mardari, Rodica
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Toldo, Irene
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Stritoni, Valent ...
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Castiglione, Ale ...
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Lovo, Elisa
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Trevisi, Patrizi ...
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Bovo, Roberto
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Martini, Alessan ...
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MEDICIN OCH HÄLS ...
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Örebro universitet