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Transcriptional cha...
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Edström, Måns,PhD,1984-Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
(författare)
Transcriptional characteristics of CD4+ T cells in multiple sclerosis: Relative lack of suppressive populations in blood
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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2010-09-16
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Sage Publications,2011
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-97547
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-97547URI
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https://doi.org/10.1177/1352458510381256DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:121810535URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-64758URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding agencies:Hospital of LinköpingLinköping Society of MedicineCounty Council of Östergötland
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Background: Multiple sclerosis (MS) is hypothetically caused by autoreactive Th1 and Th17 cells, whereas Th2 and regulatory T cells may confer protection. The development of Th subpopulations is dependant on the expression of lineage-specific transcription factors.Objective: The aim of this study was to assess the balance of CD4(+)T cell populations in relapsing-remitting MS.Methods: Blood mRNA expression of TBX21, GATA3, RORC, FOXP3 and EBI3 was assessed in 33 patients with relapsing-remitting MS and 20 healthy controls. In addition, flow cytometry was performed to assess T lymphocyte numbers.Results: In relapsing-remitting MS, diminished expression of FOXP3 (Treg) was found (p < 0.05), despite normal numbers of CD4(+)CD25(hi)Treg. Immunoregulatory EBI3 and Th2-associated GATA3 ([a-z]+) was also decreased in MS (p < 0.005 and p < 0.05, respectively). Expression of TBX21 (Th1) and RORC (Th17) did not differ between patients and controls. Similar changes were observed when analysing beta-interferon treated (n = 12) or untreated (n = 21) patients. Analysis of transcription factor ratios, comparing TBX21/GATA3 and RORC/FOXP3, revealed an increase in the RORC/FOXP3 ratio in patients with relapsing-remitting MS (p < 0.005).Conclusion: Our findings indicate systemic defects at the mRNA level, involving downregulation of beneficial CD4(+)phenotypes. This might play a role in disease development by permitting activation of harmful T cell populations.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mellergård, JohanÖstergötlands Läns Landsting,Linköpings universitet,Neurologi,Hälsouniversitetet,Neurologiska kliniken(Swepub:liu)johme15
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Mjösberg, JennyLinköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet(Swepub:liu)jenmj65
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Jenmalm, MariaLinköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)marje18
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Vrethem, MagnusÖstergötlands Läns Landsting,Linköpings universitet,Neurologi,Hälsouniversitetet,Neurologiska kliniken(Swepub:liu)magvr07
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Press, R.Karolinska Institutet,Huddinge University Hospital
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Dahle, CharlotteLinköpings universitet,Klinisk immunologi,Hälsouniversitetet(Swepub:liu)chada46
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Ernerudh, JanÖstergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin(Swepub:liu)janer15
(författare)
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Linköpings universitetKlinisk immunologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Multiple Sclerosis Journal: Sage Publications17:1, s. 57-661352-45851477-0970
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