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Mucosal Gene Transc...
Mucosal Gene Transcript Signatures in Treatment Naïve Inflammatory Bowel Disease : A Comparative Analysis of Disease to Symptomatic and Healthy Controls in the European IBD-Character Cohort
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- Vatn, Simen Svendsen (författare)
- Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway
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- Lindstrøm, Jonas Christoffer (författare)
- Health Services Research Unit (HØKH), Akershus University Hospital, Lørenskog, Norway; Department of Methods Development and Analytics, Division of Infectious Disease Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway,Akershus Univ Hosp, Norway; Norwegian Inst Publ Hlth, Norway
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- Moen, Aina E. F. (författare)
- Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Methods Development and Analytics, Division of Infectious Disease Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway; Section for Clinical Molecular Biology (EpiGen), Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Norwegian Inst Publ Hlth, Norway; Akershus Univ Hosp, Norway
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- Brackmann, Stephan (författare)
- Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway
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- Tannæs, Tone M. (författare)
- Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Section for Clinical Molecular Biology (EpiGen), Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway
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- Olbjørn, Christine (författare)
- Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Pediatric and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway
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- Bergemalm, Daniel, 1977- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology,Orebro Univ, Sweden
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- Keita, Åsa (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten
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- Gomollon, Fernando (författare)
- Digestive Diseases Unit, IIS Aragón, Zaragoza, Spain
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- Detlie, Trond Espen (författare)
- Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway
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- Lüders, Torben (författare)
- Section for Clinical Molecular Biology (EpiGen), Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Norway
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- Kalla, Rahul (författare)
- Gastrointestinal Unit, Centre for Genomics and Molecular Medicine, Division of Medical and Radiological Sciences, University of Edinburgh, Edinburgh, UK,Univ Edinburgh, Scotland
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- Adams, Alex (författare)
- Gastrointestinal Unit, Centre for Genomics and Molecular Medicine, Division of Medical and Radiological Sciences, University of Edinburgh, Edinburgh, UK; Translational Gastroenterology Unit, Medical Sciences/ Experimental medicine Division, University of Oxford, Oxford, UK,Univ Edinburgh, Scotland; Univ Oxford, England
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- Satsangi, Jack (författare)
- Gastrointestinal Unit, Centre for Genomics and Molecular Medicine, Division of Medical and Radiological Sciences, University of Edinburgh, Edinburgh, UK; Translational Gastroenterology Unit, Medical Sciences/ Experimental medicine Division, University of Oxford, Oxford, UK,Univ Edinburgh, Scotland; Univ Oxford, England
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- Jahnsen, Jørgen (författare)
- Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway
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- Vatn, Morten H. (författare)
- Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Univ Oslo, Norway
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- Halfvarson, Jonas, 1970- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology,Orebro Univ, Sweden
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- Ricanek, Petr (författare)
- Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Norway
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- Nilsen, Hilde (författare)
- Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Section for Clinical Molecular Biology (EpiGen), Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway
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(creator_code:org_t)
- Dove Medical Press Ltd. 2022
- 2022
- Engelska.
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Ingår i: Clinical and Experimental Gastroenterology. - : Dove Medical Press Ltd.. - 1178-7023. ; 15, s. 5-25
- Relaterad länk:
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https://doi.org/10.2...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Studies of the mucosal transcriptomic landscape have given new insight into the pathogenesis of inflammatory bowel disease (IBD). Recently, the predictive biomarker potential of gene expression signatures has been explored. To further investigate the mucosal gene expression in IBD, we recruited a cohort of treatment naïve patients and compared them to both symptomatic and healthy controls.Methods: Altogether, 323 subjects were included: Crohn's disease (N = 75), ulcerative colitis (N = 87) and IBD unclassified (N = 3). Additionally, there were two control groups: symptomatic controls (N = 131) and healthy controls (N = 27). Mucosal biopsies were collected during ileocolonoscopy and gene expression in inflamed and non-inflamed mucosa was explored. Gene expression profiling was performed using Agilent G3 Human Gene Expression 860K v3 One-Color microarray. We recorded information about treatment escalation to anti-TNF agents or surgery, and anti-TNF response, to explore predictive opportunities of the mucosal transcriptome.Results: Gene expression profiles in symptomatic controls in whom IBD had been excluded resembled that of IBD patients and diverged from that of healthy controls. In non-inflamed Crohn's disease and ulcerative colitis, gene set enrichment analysis revealed dysregulation of pathways involved in basic cellular biological processes. Mitochondria-associated pathways were dysregulated both in non-inflamed and inflamed Crohn's disease and ulcerative colitis (>2.6 normalized enrichment scores <-1.8). Gene expression signatures of Crohn's disease and ulcerative colitis did not predict time for treatment escalation (p = 0.175). No significant association was found between gene expression signatures and anti-TNF response.Conclusion: Non-inflamed samples are probably superior to inflamed samples when exploring gene expression signatures in IBD and might reveal underlying mechanisms central for disease initiation. The gene expression signatures of the control groups were related to if they were symptomatic or not, which may have important implications for future study designs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Crohn’s disease
- healthy controls
- mitochondria
- mucosal transcriptome
- non-inflamed
- prediction
- symptomatic controls
- ulcerative colitis
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Vatn, Simen Sven ...
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Lindstrøm, Jonas ...
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Moen, Aina E. F.
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Brackmann, Steph ...
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Tannæs, Tone M.
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Olbjørn, Christi ...
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Bergemalm, Danie ...
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Keita, Åsa
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Gomollon, Fernan ...
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Detlie, Trond Es ...
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Lüders, Torben
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Kalla, Rahul
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Adams, Alex
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Satsangi, Jack
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Jahnsen, Jørgen
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Vatn, Morten H.
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Halfvarson, Jona ...
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Ricanek, Petr
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Nilsen, Hilde
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
- Artiklar i publikationen
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Clinical and Exp ...
- Av lärosätet
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Örebro universitet
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Linköpings universitet