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Search: WFRF:(Sen Partho) > (2021) > Quantitative analys...

  • Sen, ParthoTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (author)

Quantitative analysis of human CD4+T-cell differentiation reveals subset-specific regulation of glycosphingolipid pathways

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • John Wiley & Sons,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-97873
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-97873URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:vet swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • T‐cells are sentinels of adaptive immune responses. T‐cell activation, proliferation and differentiation involves metabolic reprogramming involving the interplay of genes, proteins and metabolites. Here, we aim to understand the metabolic pathways involved in the activation and functional differentiation of human CD4+ T‐cell subsets (Th1, Th2, Th17 and iTregs). We combined genome‐scale metabolic modeling, gene expression data, targeted and non‐targeted lipidomics experiments, together with in vitro gene knockdown experiments and showed that human CD4+ T cells undergo specific metabolic changes during activation and functional differentiation. In addition, we identified and confirmed the importance of ceramide and glycosphingolipid biosynthesis pathways in Th17 differentiation and effector functions. Through in vitro gene knockdown experiments, we substantiated the requirement of serine palmitoyl transferase, a de novo sphingolipid pathway in the expression of proinflammatory cytokine (IL17A and IL17F) by Th17 cells. Our findings may provide a comprehensive resource for identifying CD4+ T‐cell‐specific targets for their selective manipulation under disease conditions, particularly, diseases characterized by an imbalance of Th17/nTreg cells. 

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Andrabi, Syed Bilal AhmadTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland (author)
  • Buchacher, TanjaTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland (author)
  • Khan, Mohd MoinTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland (author)
  • Ullah, UbaidTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland (author)
  • Lindeman, Tuomas MikaelTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (author)
  • Alves, Marina AmaralTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (author)
  • Hinkkanen, VictoriaTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (author)
  • Kemppainen, EskoTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (author)
  • Dickens, Alex M.Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (author)
  • Rasool, OmidTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland (author)
  • Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Chemistry(Swepub:oru)tihn (author)
  • Lahesmaa, RiittaTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland (author)
  • Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland(Swepub:oru)moc (author)
  • Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, FinlandTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland (creator_code:org_t)

Related titles

  • In:European Journal of Immunology: John Wiley & Sons51:Suppl. 1, s. 237-2370014-29801521-4141

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