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  • Laajala, EssiTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland; Turku Doctoral Programme of Molecular Medicine, University of Turku, Turku, Finland; Department of Computer Science, Aalto University, Espoo, Finland (author)

Umbilical cord blood DNA methylation in children who later develop type 1 diabetes

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • John Wiley & Sons,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-97895
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-97895URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:vet swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Distinct DNA methylation patterns have recently been observed to precede Type 1 Diabetes in whole blood collected from young children. Our aim was to determine if such methylation patterns are present already at the time of birth. Reduced representation bisulfite sequencing (RRBS) analysis was performed on a unique collection of umbilical cord blood samples collected within the Type 1 Diabetes Prediction and Prevention (DIPP) study. Children later diagnosed with Type 1 Diabetes and/or testing positive for multiple islet autoantibodies (N=43) were compared to control individuals (N=79), who remained autoantibody‐negative throughout the DIPP follow‐up until 15 years of age. Altogether 24 clinical and technical covariates related to the pregnancy and the mother were included in a binomial mixed effects model, which was fit separately for each high‐coverage CpG site, followed by spatial and multiple testing adjustment of P values. We discovered a strong inflation of P values, which was caused by a standard spatial adjustment method. Findings that were based on Benjamini‐Hochberg corrected spatially adjusted P values, could not be validated by Pyrosequencing. We therefore used permutation‐based significance analysis and showed that sex‐associated differentially methylated cytosines could be reproducibly detected with this approach. After empirical type 1 error control, no differences in cord blood methylation patterns were observed between cases and controls. Differences between children who progress to Type 1 Diabetes and those who remain healthy throughout childhood, are not yet present in the perinatal DNA methylome.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ullah, UbaidTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland (author)
  • Grönroos, ToniTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland (author)
  • Rasool, OmidTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland (author)
  • Aho, Viivi HallaDepartment of Computer Science, Aalto University, Espoo, Finland (author)
  • Konki, MikkoTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (author)
  • Kattelus, RoosaTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland (author)
  • Mykkänen, JuhaResearch Centre of Applied and Preventive Cardiovascular Medicine, Institute of Biomedicine, University of Turku, Turku, Finland (author)
  • Nurmio, MirjaResearch Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland (author)
  • Mäkilä, Mari VahäResearch Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland (author)
  • Kallionpää, HennaTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (author)
  • Lietzén, NiinaTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (author)
  • Laiho, AstaTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (author)
  • Hyöty, HeikkiDepartment of Virology, Faculty of Medicine and Biosciences, University of Tampere, Tampere, Finland (author)
  • Elo, Laura L.Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland (author)
  • Ilonen, JormaImmunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland (author)
  • Knip, MikaelPediatric Research Center, Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Center for Child Health Research, Tampere University Hospital, Tampere, Finland (author)
  • Lund, Riikka J.Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (author)
  • Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland(Swepub:oru)moc (author)
  • Veijola, RiittaDepartment of Pediatrics, PEDEGO Research Unit, Medical Research Centre, Oulu, Finland (author)
  • Lähdesmäki, HarriDepartment of Computer Science, Aalto University, Espoo, Finland (author)
  • Toppari, JormaResearch Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland; Department of Pediatrics, Turku University Hospital, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland (author)
  • Lahesmaa, RiittaTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland (author)
  • Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland; Turku Doctoral Programme of Molecular Medicine, University of Turku, Turku, Finland; Department of Computer Science, Aalto University, Espoo, FinlandTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland (creator_code:org_t)

Related titles

  • In:European Journal of Immunology: John Wiley & Sons51:Suppl. 1, s. 291-2910014-29801521-4141

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