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Sökning: id:"swepub:oai:DiVA.org:oru-98129" > Young adult Swedish...

  • Van't Westeinde, AnneliesKarolinska Institutet (författare)

Young adult Swedish patients with autoimmune Addison's disease report difficulties with executive functions in daily life despite overall good cognitive performance

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Elsevier,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-98129
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-98129URI
  • https://doi.org/10.1016/j.psyneuen.2022.105714DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-193226URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-187561URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:150118603URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:International Fund raising for Congenital Adrenal Hyperplasia (IFCAH)/European Society for Pediatric Endocrinology (ESPE)Foundation of Lisa and Johan GrönbergSamaritenWera Ekströms stiftelse for PediatrikforskningFoundation for Research and Education in Pediatric Endocrinology
  • Funding Agencies|Marianne and Marcus Wallenberg Foundation; Knut and Alice Wallenberg Foundation; International Fund raising for Congenital Adrenal Hyperplasia (IFCAH)/European Society for Pediatric Endocrinology (ESPE); Stockholm County Council (ALF-SLL); Swedish Research Council [DNR 2021-02440, DNR 2016-02849]; Region Stockholm [DNR RS 20191140]; Foundation of Johan Gronberg; Stiftelsen Frimurare Barnhuset i Stockholm; Samariten; Jerringfonden; Sallskapet Barnavard; Wera Ekstroms stiftelse for Pediatrikforskning; Foundation for Research and Education in Pediatric Endocrinology; Novo Nordisk Foundation; Torsten and Ragnar Soderbergs Foundations; Foundation of Lisa
  • OBJECTIVES: Sub-optimal replacement of glucocorticoids (GC) in autoimmune Addison's disease (AAD) may affect cognitive functioning. The present study therefore sought to investigate cognitive performance and self-reported problems with executive functions in a cohort of young adult patients with AAD.DESIGN AND METHODS: 67 patients with AAD (39 females), mean age 32 yrs. (range 19-41), and 80 control participants (43 females), mean age 29 yrs. (range 19-43), completed neuropsychological tests estimating verbal and non-verbal intellectual ability, learning, memory and executive functioning, in addition to self-report scales assessing problems with executive functions, fatigue and symptoms of anxiety and depression.RESULTS: Patients performed within the average range on all cognitive tests compared to population norms. However, female AAD patients reported more problems than controls with both hot (emotion regulation) and cold (cognitive regulation) executive functions in daily life. Moreover, experienced problems with executive functions in both male and female patients were associated with increased mental fatigue and lower GC replacement doses.CONCLUSIONS: Despite average performance in neuropsychological tests by both sexes, young adult female patients with AAD experience problems with executive functions in daily life. Coping with mental fatigue and optimization of pharmacotherapy may be important factors to be addressed in order to provide timely support for patients. Future research is needed to further determine other risk factors for experiencing executive function impairments in AAD.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ström, SaraKarolinska Institutet (författare)
  • Hirvikoski, TatjaKarolinska Institutet (författare)
  • Dahlqvist, PerUmeå universitet,Avdelningen för medicin,Umea Univ, Sweden(Swepub:umu)perdat96 (författare)
  • Wahlberg, Jeanette,1969-Linköpings universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Endocrinology and Department of Medical and Health Sciences, Linköpings University, Linköping, Sweden; Department of Internal Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken,Orebro Univ, Sweden(Swepub:liu)jeawa98 (författare)
  • Gezelius, AntonDepartment of Women's and Children's Health, Karolinska Institutet, Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Sweden (författare)
  • Kämpe, OlleDepartment of Medicine (Solna), Center for Molecular Medicine, Karolinska Institutet, Sweden,Karolinska Inst, Sweden (författare)
  • Bensing, SophieDepartment of Molecular Medicine and Surgery, Karolinska Institutet and Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (författare)
  • Lajic, SvetlanaDepartment of Women's and Children's Health, Karolinska Institutet, Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Sweden (författare)
  • Karolinska InstitutetAvdelningen för medicin (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Psychoneuroendocrinology: Elsevier1400306-45301873-3360

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