The Ageing Gut, in Health and Disease

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Fart, Frida,1992-Örebro universitet,Institutionen för medicinska vetenskaper (författare)

The Ageing Gut, in Health and Disease

BokEngelska2022

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Örebro :Örebro University,2022
90 s.
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:oru-98220
ISBN:9789175294513
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-98220URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:vet swepub-contenttype
Ämneskategori:dok swepub-publicationtype

Serie

Örebro Studies in Medicine,1652-4063 ;268

Anmärkningar

There is a global ageing phenomenon, which stress the importance for an improved health for the increased population of older adults. One important factor for a good health is a well-functioning gut. Hence, this thesisinvestigates several aspects of gut health for older adults, spanning from overall gut health in community-dwelling older adults, to investigating a gut disease model: inflammatory bowel disease, which includes Crohn’s disease and ulcerative colitis. When investigating community-dwelling older adults, gastrointestinal symptoms were found to be common and correlated to a lower experience of well-being. In addition, more than half of the population did not reach the recommended intake of several macronutrients, including protein and fibre. Compared to a group of active older adults, still practising orienteering, i.e., senior orienteers, community-dwelling older adult’s further showed signs of a less healthier gut microbiota, including lower levels of Faecalibacterium prausnitzii.By investigating the disease model of inflammatory bowel disease, later onset of Crohn’s disease seemed to have less hyperresponsive adaptive immune response toward the own gut microbiota, which seems to be due to a less genetic predisposition among later onset individuals. Interestingly, an environmental pollutant, per- and polyfluoroalkyl substances (PFAS), was increased in the serum of late-onset ulcerative colitis patients compared to healthy controls. A higher level of PFAS further correlated to a disturbed bile acid pool. In addition, PFAS induced an increased intestinal permeability across ileal and colonic murine tissue. In conclusion, the work included in this thesis further emphasises the importance of a maintained gut health. In addition, the work highlights diet, an active life-style, gut microbiota and environmental factors, for example PFAS, as targets of future interventions studies with the aim to improve gut health and overall health among older adults.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Allmänmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine General Practice hsv//eng
Older adults
gut health
gastrointestinal symptoms
gut microbiota
nutrition
physical activity
inflammatory bowel disease
late-onset
per- and polyfluoroalkyl substances

Biuppslag (personer, institutioner, konferenser, titlar ...)

Schoultz, Ida,docent,1979-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)isz (preses)
Halfvarson, Jonas,professor,1970-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)jshn (preses)
Kihlgren, Annica,professor,1957-Örebro universitet,Institutionen för hälsovetenskaper(Swepub:oru)ackn (preses)
Cederholm, Tommy,professorUppsala universitet, Uppsala (opponent)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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Av författaren/redakt...: Fart, Frida, 199 ...; Schoultz, Ida, d ...; Halfvarson, Jona ...; Kihlgren, Annica ...; Cederholm, Tommy ...

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Av lärosätet: Örebro universitet

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