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The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs)

Behzadi, Payam (författare)
Department of Microbiology, College of Basic Sciences, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran
Sameer, Aga Syed (författare)
Molecular Disease & Diagnosis Division, Infinity Biochemistry Pvt. Ltd, Sajjad Abad, Chattabal, Srinagar, Kashmir, India; Department of Biochemistry, Government Medical College, Karan Nagar, Srinagar, Kashmir, India
Nissar, Saniya (författare)
Molecular Disease & Diagnosis Division, Infinity Biochemistry Pvt. Ltd, Sajjad Abad, Chattabal, Srinagar, Kashmir, India; Department of Biochemistry, Government Medical College, Karan Nagar, Srinagar, Kashmir, India
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Banday, Mujeeb Zafar (författare)
Molecular Disease & Diagnosis Division, Infinity Biochemistry Pvt. Ltd, Sajjad Abad, Chattabal, Srinagar, Kashmir, India; Department of Biochemistry, Government Medical College, Karan Nagar, Srinagar, Kashmir, India
Gajdács, Márió (författare)
Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Szeged, Hungary
García-Perdomo, Herney Andrés (författare)
Division of Urology, Department of Surgery, School of Medicine, UROGIV Research Group, Universidad del Valle, Cali, Colombia
Akhtar, Kulsum (författare)
Department of Clinical Biochemistry, Sher I Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India
Pinheiro, Marina (författare)
Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, Porto, Portugal; CHUP, Centro Hospitalar Universitário do Porto, Largo do Prof. Abel Salazar, Porto, Portugal
Magnusson, Peter, 1973- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Cardiology Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Sarshar, Meysam (författare)
Research Laboratories, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy
Ambrosi, Cecilia (författare)
IRCCS San Raffaele Roma, Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy
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Department of Microbiology, College of Basic Sciences, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran Molecular Disease & Diagnosis Division, Infinity Biochemistry Pvt Ltd, Sajjad Abad, Chattabal, Srinagar, Kashmir, India; Department of Biochemistry, Government Medical College, Karan Nagar, Srinagar, Kashmir, India (creator_code:org_t)
Hindawi Publishing Corporation, 2022
2022
Engelska.
Ingår i: Journal of Immunology Research. - : Hindawi Publishing Corporation. - 2314-8861 .- 2314-7156. ; 2022
Relaterad länk:
https://doi.org/10.1...
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https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
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  • Interleukins (ILs)-which are important members of cytokines-consist of a vast group of molecules, including a wide range of immune mediators that contribute to the immunological responses of many cells and tissues. ILs are immune-glycoproteins, which directly contribute to the growth, activation, adhesion, differentiation, migration, proliferation, and maturation of immune cells; and subsequently, they are involved in the pro and anti-inflammatory responses of the body, by their interaction with a wide range of receptors. Due to the importance of immune system in different organisms, the genes belonging to immune elements, such as ILs, have been studied vigorously. The results of recent investigations showed that the genes pertaining to the immune system undergo progressive evolution with a constant rate. The occurrence of any mutation or polymorphism in IL genes may result in substantial changes in their biology and function and may be associated with a wide range of diseases and disorders. Among these abnormalities, single nucleotide polymorphisms (SNPs) can represent as important disruptive factors. The present review aims at concisely summarizing the current knowledge available on the occurrence, properties, role, and biological consequences of SNPs within the IL-1 family members.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)
NATURVETENSKAP  -- Biologi -- Immunologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Immunology (hsv//eng)

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