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The role of ADHD ge...
The role of ADHD genetic risk in mid-to-late life somatic health conditions
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- Garcia-Argibay, Miguel, 1988- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- du Rietz, Ebba (författare)
- Karolinska Institutet
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- Lu, Yi (författare)
- Karolinska Institutet
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- Martin, Joanna (författare)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK
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- Haan, Elis (författare)
- Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia
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- Letho, Kelli (författare)
- Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia
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- Bergen, Sarah E. (författare)
- Karolinska Institutet
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- Lichtenstein, Paul (författare)
- Karolinska Institutet
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- Larsson, Henrik, 1975- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Brikell, Isabell (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-04-11
- 2022
- Engelska.
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Ingår i: Translational Psychiatry. - : Nature Publishing Group. - 2158-3188. ; 12:1
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Growing evidence suggests that ADHD, an early onset neurodevelopmental disorder, is associated with poor somatic health in adulthood. However, the mechanisms underlying these associations are poorly understood. Here, we tested whether ADHD polygenic risk scores (PRS) are associated with mid-to-late life somatic health in a general population sample. Furthermore, we explored whether potential associations were moderated and mediated by life-course risk factors. We derived ADHD-PRS in 10,645 Swedish twins born between 1911 and 1958. Sixteen cardiometabolic, autoimmune/inflammatory, and neurological health conditions were evaluated using self-report (age range at measure 42-88 years) and clinical diagnoses defined by International Classification of Diseases codes in national registers. We estimated associations of ADHD-PRS with somatic outcomes using generalized estimating equations, and tested moderation and mediation of these associations by four life-course risk factors (education level, body mass index [BMI], tobacco use, alcohol misuse). Results showed that higher ADHD-PRS were associated with increased risk of seven somatic outcomes (heart failure, cerebro- and peripheral vascular disease, obesity, type 1 diabetes, rheumatoid arthritis, and migraine) with odds ratios ranging 1.07 to 1.20. We observed significant mediation effects by education, BMI, tobacco use, and alcohol misuse, primarily for associations of ADHD-PRS with cardiometabolic outcomes. No moderation effects survived multiple testing correction. Our findings suggests that higher ADHD genetic liability confers a modest risk increase for several somatic health problems in mid-to-late life, particularly in the cardiometabolic domain. These associations were observable in the general population, even in the absence of medical treatment for ADHD, and appear to be in part mediated by life-course risk factors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
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Garcia-Argibay, ...
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du Rietz, Ebba
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Lu, Yi
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Martin, Joanna
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Haan, Elis
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Letho, Kelli
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visa fler...
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Bergen, Sarah E.
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Lichtenstein, Pa ...
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Larsson, Henrik, ...
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Brikell, Isabell
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Translational Ps ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet