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  • Edebol Carlman, Hanna M. T.Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Sweden,Nutrition-Gut-Brain Interactions Research Centre (author)

Probiotic Mixture Containing Lactobacillus helveticus, Bifidobacterium longum and Lactiplantibacillus plantarum Affects Brain Responses to an Arithmetic Stress Task in Healthy Subjects : A Randomised Clinical Trial and Proof-of-Concept Study

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-03-22
  • MDPI,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-98559
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-98559URI
  • https://doi.org/10.3390/nu14071329DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:149278789URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies:Global Medical InnovationPfizer Consumer HealthcareGeneral Electric 20150081
  • Probiotics are suggested to impact physiological and psychological stress responses by acting on the gut-brain axis. We investigated if a probiotic product containing Bifidobacterium longum R0175, Lactobacillus helveticus R0052 and Lactiplantibacillus plantarum R1012 affected stress processing in a double-blinded, randomised, placebo-controlled, crossover proof-of-concept study (NCT03615651). Twenty-two healthy subjects (24.2 ± 3.4 years, 6 men/16 women) underwent a probiotic and placebo intervention for 4 weeks each, separated by a 4-week washout period. Subjects were examined by functional magnetic resonance imaging while performing the Montreal Imaging Stress Task (MIST) as well as an autonomic nervous system function assessment during the Stroop task. Reduced activation in regions of the lateral orbital and ventral cingulate gyri was observed after probiotic intervention compared to placebo. Significantly increased functional connectivity was found between the upper limbic region and medioventral area. Interestingly, probiotic intervention seemed to predominantly affect the initial stress response. Salivary cortisol secretion during the task was not altered. Probiotic intervention did not affect cognitive performance and autonomic nervous system function during Stroop. The probiotic intervention was able to subtly alter brain activity and functional connectivity in regions known to regulate emotion and stress responses. These findings support the potential of probiotics as a non-pharmaceutical treatment modality for stress-related disorders.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rode, Julia,1992-Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre(Swepub:oru)jre (author)
  • König, Julia,1983-Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre(Swepub:oru)jkg (author)
  • Repsilber, Dirk,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre(Swepub:oru)drr (author)
  • Hutchinson, Ashley,1984-Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre(Swepub:oru)ayhn (author)
  • Thunberg, Per,1968-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Radiology and Medical Physics(Swepub:oru)prtg (author)
  • Persson, Jonas,1971-Karolinska Institutet,Örebro universitet,Institutionen för juridik, psykologi och socialt arbete,Center for Lifespan Developmental Research (LEADER)(Swepub:oru)jspn (author)
  • Kiselev, Andrey,1982-Örebro universitet,Institutionen för naturvetenskap och teknik,Center for Applied Autonomous Sensor Systems(Swepub:oru)akv (author)
  • Pruessner, Jens C.Douglas Institute, McGill University, Montréal, QC H4H1R3, Canada; Department of Psychology, University of Konstanz, Konstanz, Germany (author)
  • Brummer, Robert Jan,1957-Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre(Swepub:oru)rnbr (author)
  • Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, SwedenNutrition-Gut-Brain Interactions Research Centre (creator_code:org_t)

Related titles

  • In:Nutrients: MDPI14:72072-6643

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