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Probiotic Mixture C...
Probiotic Mixture Containing Lactobacillus helveticus, Bifidobacterium longum and Lactiplantibacillus plantarum Affects Brain Responses to an Arithmetic Stress Task in Healthy Subjects : A Randomised Clinical Trial and Proof-of-Concept Study
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- Edebol Carlman, Hanna M. T. (författare)
- Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Sweden,Nutrition-Gut-Brain Interactions Research Centre
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- Rode, Julia, 1992- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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- König, Julia, 1983- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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- Repsilber, Dirk, 1971- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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- Hutchinson, Ashley, 1984- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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- Thunberg, Per, 1968- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Radiology and Medical Physics
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- Persson, Jonas, 1971- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för juridik, psykologi och socialt arbete,Center for Lifespan Developmental Research (LEADER)
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- Kiselev, Andrey, 1982- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Center for Applied Autonomous Sensor Systems
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- Pruessner, Jens C. (författare)
- Douglas Institute, McGill University, Montréal, QC H4H1R3, Canada; Department of Psychology, University of Konstanz, Konstanz, Germany
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- Brummer, Robert Jan, 1957- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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(creator_code:org_t)
- 2022-03-22
- 2022
- Engelska.
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Ingår i: Nutrients. - : MDPI. - 2072-6643. ; 14:7
- Relaterad länk:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Probiotics are suggested to impact physiological and psychological stress responses by acting on the gut-brain axis. We investigated if a probiotic product containing Bifidobacterium longum R0175, Lactobacillus helveticus R0052 and Lactiplantibacillus plantarum R1012 affected stress processing in a double-blinded, randomised, placebo-controlled, crossover proof-of-concept study (NCT03615651). Twenty-two healthy subjects (24.2 ± 3.4 years, 6 men/16 women) underwent a probiotic and placebo intervention for 4 weeks each, separated by a 4-week washout period. Subjects were examined by functional magnetic resonance imaging while performing the Montreal Imaging Stress Task (MIST) as well as an autonomic nervous system function assessment during the Stroop task. Reduced activation in regions of the lateral orbital and ventral cingulate gyri was observed after probiotic intervention compared to placebo. Significantly increased functional connectivity was found between the upper limbic region and medioventral area. Interestingly, probiotic intervention seemed to predominantly affect the initial stress response. Salivary cortisol secretion during the task was not altered. Probiotic intervention did not affect cognitive performance and autonomic nervous system function during Stroop. The probiotic intervention was able to subtly alter brain activity and functional connectivity in regions known to regulate emotion and stress responses. These findings support the potential of probiotics as a non-pharmaceutical treatment modality for stress-related disorders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Montreal Imaging Stress Task (MIST)
- autonomic nervous system
- brain activity
- functional magnetic resonance imaging (fMRI)
- gut microbiota
- gut-brain axis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Edebol Carlman, ...
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Rode, Julia, 199 ...
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König, Julia, 19 ...
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Repsilber, Dirk, ...
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Hutchinson, Ashl ...
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Thunberg, Per, 1 ...
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Persson, Jonas, ...
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Kiselev, Andrey, ...
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Pruessner, Jens ...
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Brummer, Robert ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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och Näringslära
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MEDICIN OCH HÄLS ...
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och Neurovetenskaper
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Nutrients
- Av lärosätet
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Örebro universitet
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Karolinska Institutet