Sökning: WFRF:(Paschalidis N.) >
Immunomodulating Ac...
Immunomodulating Activity of Pleurotus eryngii Mushrooms Following Their In Vitro Fermentation by Human Fecal Microbiota
-
- Vlassopoulou, Marigoula (författare)
- Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece; Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
-
- Paschalidis, Nikolaos (författare)
- CyTOF Laboratory, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece
-
- Savvides, Alexandros L. (författare)
- Microbiology Group, Department of Botany, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimioupolis, Zografou, Athens, Greece
-
visa fler...
-
- Saxami, Georgia (författare)
- Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
-
- Mitsou, Evdokia K. (författare)
- Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
-
- Kerezoudi, Evangelia N., 1995- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Nutrition and Dietetics, Harokopio University, Athens, Greece;
-
- Koutrotsios, Georgios (författare)
- Laboratory of General and Agricultural Microbiology, Department of Crop Science, Agricultural University of Athens, Athens, Greece
-
- Zervakis, Georgios, I (författare)
- Laboratory of General and Agricultural Microbiology, Department of Crop Science, Agricultural University of Athens, Athens, Greece
-
- Georgiadis, Panagiotis (författare)
- Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece
-
- Kyriacou, Adamantini (författare)
- Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
-
- Pletsa, Vasiliki (författare)
- Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece
-
visa färre...
-
(creator_code:org_t)
- 2022-03-22
- 2022
- Engelska.
-
Ingår i: Journal of fungi (JoF). - : MDPI. - 2309-608X. ; 8:4
- Relaterad länk:
-
https://doi.org/10.3...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Recent studies have revealed the crucial role of several edible mushrooms and fungal compounds, mainly polysaccharides, in human health and disease. The investigation of the immunomodulating effects of mushroom polysaccharides, especially beta-glucans, and the link between their anticancer and immunomodulatory properties with their possible prebiotic activity on gut micro-organisms has been the subject of intense research over the last decade. We investigated the immunomodulating effects of Pleurotus eryngii mushrooms, selected due to their high beta-glucan content, strong lactogenic effect, and potent geno-protective properties, following in vitro fermentation by fecal inocula from healthy elderly volunteers (>60 years old). The immunomodulating properties of the fermentation supernatants (FSs) were initially investigated in U937-derived human macrophages. Gene expression as well as pro- (TNF-alpha, IL-1 beta) and anti-inflammatory cytokines (IL-10, IL-1R alpha) were assessed and correlated with the fermentation process. The presence of P. eryngii in the fermentation process led to modifications in immune response, as indicated by the altered gene expression and levels of the cytokines examined, a finding consistent for all volunteers. The FSs immunomodulating effect on the volunteers' peripheral blood mononuclear cells (PBMCs) was verified through the use of cytometry by time of flight (CyTOF) analysis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- edible mushrooms
- macrophages
- cytokines
- PBMCs
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Vlassopoulou, Ma ...
-
Paschalidis, Nik ...
-
Savvides, Alexan ...
-
Saxami, Georgia
-
Mitsou, Evdokia ...
-
Kerezoudi, Evang ...
-
visa fler...
-
Koutrotsios, Geo ...
-
Zervakis, Georgi ...
-
Georgiadis, Pana ...
-
Kyriacou, Adaman ...
-
Pletsa, Vasiliki
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinsk biotek ...
-
och Medicinsk biotek ...
- Artiklar i publikationen
-
Journal of fungi ...
- Av lärosätet
-
Örebro universitet