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Effects of age, amy...
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Wesenhagen, Kirsten E. J.Alzheimer Center Amsterdam, Department of Neurology, Amsterdam, the Netherlands; Neuroscience, Amsterdam UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
(författare)
Effects of age, amyloid, sex, and APOE ε4 on the CSF proteome in normal cognition
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-05-06
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John Wiley & Sons,2022
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-99029
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-99029URI
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https://doi.org/10.1002/dad2.12286DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies:ZonMW Memorabel grant programme 733050824Innovative Medicines Initiative Joint Undertaking under EMIF-AD MBD grant 115372Swedish State Support for Clinical Research
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Introduction: It is important to understand which biological processes change with aging, and how such changes are associated with increased Alzheimer's disease (AD) risk. We studied how cerebrospinal fluid (CSF) proteomics changed with age and tested if associations depended on amyloid status, sex, and apolipoprotein E Ɛ4 genotype.Methods: We included 277 cognitively intact individuals aged 46 to 89 years from Alzheimer's Disease Neuroimaging Initiative, European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery, and Metabolic Syndrome in Men. In total, 1149 proteins were measured with liquid chromatography mass spectrometry with multiple reaction monitoring/Rules-Based Medicine, tandem mass tag mass spectrometry, and SOMAscan. We tested associations between age and protein levels in linear models and tested enrichment for Reactome pathways.Results: Levels of 252 proteins increased with age independently of amyloid status. These proteins were associated with immune and signaling processes. Levels of 21 proteins decreased with older age exclusively in amyloid abnormal participants and these were enriched for extracellular matrix organization.Discussion: We found amyloid-independent and -dependent CSF proteome changes with older age, perhaps representing physiological aging and early AD pathology.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Gobom, JohanClinical Neurochemistry Lab, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden
(författare)
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Bos, IsabelleNivel, the Netherlands
(författare)
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Vos, Stephanie J. B.Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands
(författare)
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Martinez-Lage, PabloCenter for Research and Advanced Therapies, CITA-Alzheimers Foundation, Donostia-San Sebastian, Spain
(författare)
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Popp, JuliusGeriatric Psychiatry, Department of Mental Health and Psychiatry, Geneva University Hospitals, Geneva, Switzerland; Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland
(författare)
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Tsolaki, Magda1st Department of Neurology, AHEPA University Hospital, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, Makedonia, Thessaloniki, Greece
(författare)
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Vandenberghe, RikNeurology Service, University Hospitals Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium
(författare)
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Freund-Levi, Yvonne,1956-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden; Dep of Psychiatry, Örebro University Hospital, Örebro, Sweden(Swepub:oru)yfi
(författare)
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Verhey, FransAlzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands
(författare)
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Lovestone, SimonJanssen-cilag, High Wycombe, UK; University of Oxford, Oxford, UK
(författare)
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Streffer, Johannesformerly Janssen R&D, LLC, Beerse, Belgium (AC Immune SA, Lausanne, Switzerland; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
(författare)
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Dobricic, ValerijaLübeck University, Lübeck, Germany
(författare)
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Bertram, LarsLübeck University, Lübeck, Germany; Center for Lifespan Changes in Brain and Cognition (LCBC), Department of Psychology, University of Oslo, Oslo, Norway
(författare)
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Blennow, KajClinical Neurochemistry Lab, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden,Alzheimer's Disease Neuroimaging Initiative
(författare)
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Pikkarainen, MariaInstitute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
(författare)
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Hallikainen, MerjaInstitute of Clinical Medicine Internal Medicine and Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland
(författare)
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Kuusisto, JohannaInstitute of Clinical Medicine Internal Medicine and Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland
(författare)
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Laakso, MarkkuInstitute of Clinical Medicine Internal Medicine and Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland
(författare)
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Soininen, HilkkaInstitute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
(författare)
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Scheltens, PhilipAlzheimer Center Amsterdam, Department of Neurology, Amsterdam, the Netherlands; Neuroscience, Amsterdam UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
(författare)
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Zetterberg, HenrikClinical Neurochemistry Lab, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease UCL, Institute of Neurology, London, UK; UK Dementia Research Institute, London, UK; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden
(författare)
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Teunissen, Charlotte E.Neurochemistry Lab, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands
(författare)
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Visser, Pieter JelleAlzheimer Center Amsterdam, Department of Neurology, Amsterdam, the Netherlands; Neuroscience, Amsterdam UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands; Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden
(författare)
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Tijms, Betty M.Alzheimer Center Amsterdam, Department of Neurology, Amsterdam, the Netherlands; Neuroscience, Amsterdam UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
(författare)
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Alzheimer Center Amsterdam, Department of Neurology, Amsterdam, the Netherlands; Neuroscience, Amsterdam UMC Vrije Universiteit Amsterdam, Amsterdam, the NetherlandsClinical Neurochemistry Lab, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Alzheimer's & dementia (Amsterdam, Netherlands): John Wiley & Sons14:12352-8729
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Wesenhagen, Kirs ...
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Gobom, Johan
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Bos, Isabelle
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Vos, Stephanie J ...
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Martinez-Lage, P ...
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Popp, Julius
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visa fler...
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Tsolaki, Magda
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Vandenberghe, Ri ...
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Freund-Levi, Yvo ...
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Verhey, Frans
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Lovestone, Simon
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Streffer, Johann ...
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Dobricic, Valeri ...
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Bertram, Lars
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Blennow, Kaj
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Pikkarainen, Mar ...
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Hallikainen, Mer ...
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Kuusisto, Johann ...
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Laakso, Markku
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Soininen, Hilkka
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Scheltens, Phili ...
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Zetterberg, Henr ...
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Teunissen, Charl ...
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Visser, Pieter J ...
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Tijms, Betty M.
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