Interventions for the management of Pain and Sedation in Newborns undergoing Therapeutic hypothermia for hypoxic-ischemic encephalopathy (IPSNUT): protocol of a systematic review

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Bäcke, PyrolaUppsala University,Uppsala universitet,Institutionen för kvinnors och barns hälsa,Univ Hosp, Neonatal Intens Care Unit, Uppsala, Sweden.,Uppsala University Hospital (author)

Interventions for the management of Pain and Sedation in Newborns undergoing Therapeutic hypothermia for hypoxic-ischemic encephalopathy (IPSNUT) : protocol of a systematic review

Article/chapterEnglish2022

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2022-05-23
BioMed Central,2022
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LIBRIS-ID:oai:DiVA.org:oru-99163
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-99163URI
https://doi.org/10.1186/s13643-022-01982-9DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-476843URI
https://lup.lub.lu.se/record/07aec55b-b3ec-49ca-8bd9-d962bd92ecbcURI

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Language:English
Summary in:English

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Subject category:for swepub-publicationtype

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BACKGROUND: Clinical research has shown that therapeutic hypothermia after neonatal hypoxic-ischemic injury improves survival without disability. There is no consensus regarding pain relief or sedation during therapeutic hypothermia in newborns; however, therapeutic hypothermia seems to be associated with pain and stress, and adequate analgesia and sedation are central to maximize the effect of therapeutic hypothermia. Pain needs to be adequately managed in all patients, especially the newborn infant due to the potential short- and long-term negative effects of inadequately treated pain in this population.METHODS: We will perform a systematic review of pharmacological and non-pharmacological interventions for the management of pain and sedation in newborn infants undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy. We will include randomized, quasi-randomized controlled trials and observational studies. The use of pharmacological or non-pharmacological interventions will be compared to other pharmacological and or non-pharmacological interventions or no intervention/placebo. The primary outcomes for this review will be analgesia and sedation assessed with validated pain scales, circulatory instability, mortality to discharge, and moderate-to-severe neurodevelopmental disability. We will search the following databases: CINAHL, ClinicalTrials.gov , Cochrane Library, Embase, PubMed, Scopus, and Web of Science. Two independent researchers will screen the records for inclusion, extract data using a data extraction form, and assess the risk of bias in the included trials.DISCUSSION: The result of this review will summarize the knowledge regarding the management of pain and sedation in infants treated with therapeutic hypothermia and potentially provide clinicians with guidance on the effective and safe methods.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Anestesi och intensivvård hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Anesthesiology and Intensive Care hsv//eng
Asphyxia
Cooling
Hypoxic-ischemic encephalopathy
Neonatal
Pain scale
Therapeutic hypothermia
Asphyxia
Cooling
Hypoxic-ischemic encephalopathy
Neonatal
Pain scale
Therapeutic hypothermia

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Bruschettini, MatteoLund University,Lunds universitet,Neonatalogi,Forskargrupper vid Lunds universitet,Neonatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-mb14 (author)
Thernström Blomqvist, Ylva,1974-Uppsala University,Uppsala universitet,Perinatal, neonatal och barnkardiologisk forskning,Univ Hosp, Neonatal Intens Care Unit, Uppsala, Sweden.,Uppsala University Hospital(Swepub:uu)ylvbl441 (author)
Olsson, Emma,1980-Örebro University,Örebro universitet,Institutionen för hälsovetenskaper,Department of Pediatrics,Örebro Univ, Fac Med & Hlth, Dept Pediat, Örebro, Sweden.;Örebro Univ, Sch Hlth Sci, Fac Med & Hlth, S-70182 Örebro, Sweden.(Swepub:oru)emon (author)
Uppsala universitetInstitutionen för kvinnors och barns hälsa (creator_code:org_t)

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In:Systematic Reviews: BioMed Central11:12046-4053

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