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  • Mouratidou, NataliaAstrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden; 2Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden,Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Med Solna, Div Clin Epidemiol, Stockholm, Sweden. (författare)

Identification of Childhood-Onset Inflammatory Bowel Disease in Swedish Healthcare Registers : A Validation Study

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Dove Medical Press Ltd.2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-99216
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-99216URI
  • https://doi.org/10.2147/CLEP.S358031DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-195068URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-476107URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:149639332URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:Crown Princess Louisa's memory fundMag-tarmfondenBengt Ihre foundation
  • Purpose: The Swedish National Patient Register (NPR) is often used in observational studies of childhood-onset inflammatory bowel disease (IBD) (<18 years of age) and its subtypes, but the validity of previously used register-based algorithms for capturing childhood-onset IBD has never been examined.Methods: We identified a random sample of 233 individuals with at least two first ever diagnostic listings of IBD in the NPR between 2002 and 2014. We calculated the test characteristics for different register-based definitions of IBD and its subtypes using the Copenhagen criteria and the revised Porto criteria as gold standard, both based on medical chart review. We made assumptions of the occurrence of undiagnosed IBD in the general child population based on available literature.Results: Out of 233 individuals with at least two diagnostic listings of IBD, 216 had true IBD, resulting in a positive predictive value (PPV) = 93% (95% confidence interval (CI) 89-96), sensitivity = 88% (95% CI 83-92), specificity = 100% (95% CI 100-100), and negative predictive value (NPV) = 100% (95% CI 100-100). The PPV for the NPR-based definitions of IBD subtypes at time of first IBD diagnosis and at end of follow-up were 78% (95% CI 69-86) and 88% (95% CI 80-94), respectively, for Crohn's disease and 74% (95% CI 63-83) and 71% (95% CI 60-80), respectively, for ulcerative colitis.Conclusion: The validity of register-based definitions of childhood-onset IBD in the Swedish NPR is high and can be used to identify patients in observational research.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Malmborg, PetterKarolinska Institutet (författare)
  • Järås, JacobKarolinska Institutet (författare)
  • Sigurdsson, VignirDepartment of Pediatrics, Institute of Clinical Sciences, The Sahlgrenska Academy at University of Gothenburg and Queen Silvia’s Children’s Hospital, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden.;Queen Silvias Childrens Hosp, Gothenburg, Sweden. (författare)
  • Sandström, OlofUmeå universitet,Pediatrik,Umeå Univ, Dept Clin Sci, Pediat, Umeå, Sweden.(Swepub:umu)olsa0022 (författare)
  • Fagerberg, Ulrika L.Uppsala universitet,Centrum för klinisk forskning, Västerås,Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.(Swepub:uu)ulrfa951 (författare)
  • Bröms, GabriellaKarolinska Institutet (författare)
  • Ludvigsson, Jonas F.,1969-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,9Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden,Karolinska Inst, Dept Med Epidemiol & Biostat, Solna, Sweden.;Örebro Univ Hosp, Dept Pediat, Örebro, Sweden.(Swepub:oru)jsln (författare)
  • Olén, OlaKarolinska Institutet (författare)
  • Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden; 2Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, SwedenKarolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Med Solna, Div Clin Epidemiol, Stockholm, Sweden. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Clinical Epidemiology: Dove Medical Press Ltd.14, s. 591-6001179-1349

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