The Effectiveness and Tolerability of a Very Low-Volume Bowel Preparation for Colonoscopy Compared to Low and High-Volume Polyethylene Glycol-Solutions in the Real-Life Setting

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Bednarska, OlgaLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken,Linköping University Hospital (author)

The Effectiveness and Tolerability of a Very Low-Volume Bowel Preparation for Colonoscopy Compared to Low and High-Volume Polyethylene Glycol-Solutions in the Real-Life Setting

Article/chapterEnglish2022

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2022-05-06
Basel, Switzerland :MDPI,2022
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LIBRIS-ID:oai:DiVA.org:oru-99443
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-99443URI
https://doi.org/10.3390/diagnostics12051155DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-185843URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:149704671URI
https://lup.lub.lu.se/record/dc490b29-17ae-4847-bb58-17ccb2da2d55URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Funding Agencies: The authors, except G.W.J., disclosed receipt of an unrestricted financial grant of 50,000 Swedish krona from Norgine prior to conducting this study.
Adequate bowel cleansing is essential for high-quality colonoscopy. Recently, a new very low-volume 1 litre (1L) polyethylene glycol (PEG) plus ascorbate solution (ASC) has been introduced. Our aims were to assess the effectiveness and tolerability of this product compared to low-volume 2L PEG-ASC and high-volume 4L PEG solutions, in a real-life setting. In six endoscopy units in Sweden, outpatients undergoing colonoscopy were either prescribed solutions according to local routines, or the very low-volume solution in split dose regimen. Bowel cleansing effectiveness and patient experience was assessed using the Boston Bowel preparation scale (BBPS) and a patient questionnaire. A total of 1098 patients (mean age 58 years, 52% women) were included. All subsegment and the total BBPS scores were significantly greater for 1L PEG-ASC in comparison to other solutions (p < 0.05 for 1L PEG-ASC and 4L PEG for transverse and left colon, otherwise p < 0.001). Nausea was more frequent with 1L PEG-ASC compared to 2L PEG-ASC (p < 0.001) and vomiting were more often reported compared to both other solutions (p < 0.01 and p < 0.05 for 2L PEG-ASC and 4L PEG, respectively). Smell, taste, and total experience was better for 1L PEG-ASC compared to 4L PEG (p < 0.001), and similar compared to the 2L PEG-ASC. In conclusion, 1L PEG-ASC leads to better bowel cleansing compared to 2L PEG-ASC or 4L PEG products, with similar or greater patient satisfaction.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
bowel preparation
colonoscopy
polyethylene glycol
polyethylene glycol plus ascorbate
effectiveness
tolerability
bowel preparation
colonoscopy
effectiveness
polyethylene glycol
polyethylene glycol plus ascorbate
tolerability

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Nyhlin, Nils,1971-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology,Örebro Univ, Sweden(Swepub:oru)nnn (author)
Schmidt, Peter ThelinKarolinska Institute,Ersta Hospital (author)
Johansson, Gabriele WurmLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-giw (author)
Toth, ErvinLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)ront-eto (author)
Lindfors, PerjohanKarolinska Institute,Karolinska Institutet,Aleris Gastromottagningen City (author)
Linköpings universitetAvdelningen för inflammation och infektion (creator_code:org_t)

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In:DiagnosticsBasel, Switzerland : MDPI12:52075-4418

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