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  • Laajala, EssiTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland; Turku Doctoral Programme of Molecular Medicine, University of Turku, Turku, Finland; Department of Computer Science, Aalto University, Espoo, Finland (author)

Umbilical cord blood DNA methylation in children who later develop type 1 diabetes

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-06-18
  • Springer,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-99651
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-99651URI
  • https://doi.org/10.1007/s00125-022-05726-1DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies:University of Turku (UTU)InFLAMES Flagship Programme of the Academy of Finland 337530Juvenile Diabetes Research Foundation 1-SRA-2016-342-M-R 1-SRA-2019-732-M-BFinnish Diabetes FoundationSpecial Research Funds for University Hospitals in FinlandBusiness FinlandSigrid Juselius FoundationJane and Aatos Erkko FoundationFinnish Cancer FoundationTurku University Central HospitalAcademy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research (2012-2017) 250114 292482 European Foundation for the Study of DiabetesPediatric Research FoundationTurku University Hospital Special Governmental GrantsBiocenter FinlandELIXIR FinlandTurku Doctoral Programme of Molecular MedicineFinnish Cultural FoundationFinnish IT center for science Kyllikki and Uolevi Lehikoinen Foundation 
  • AIMS/HYPOTHESIS: Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine whether perinatal DNA methylation is associated with later progression to type 1 diabetes.METHODS: Reduced representation bisulphite sequencing (RRBS) analysis was performed on umbilical cord blood samples collected within the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Study. Children later diagnosed with type 1 diabetes and/or who tested positive for multiple islet autoantibodies (n = 43) were compared with control individuals (n = 79) who remained autoantibody-negative throughout the DIPP follow-up until 15 years of age. Potential confounding factors related to the pregnancy and the mother were included in the analysis.RESULTS: No differences in the umbilical cord blood methylation patterns were observed between the cases and controls at a false discovery rate <0.05.CONCLUSIONS/INTERPRETATION: Based on our results, differences between children who progress to type 1 diabetes and those who remain healthy throughout childhood are not yet present in the perinatal DNA methylome. However, we cannot exclude the possibility that such differences would be found in a larger dataset.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kalim, Ubaid UllahTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland (author)
  • Grönroos, ToniTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland (author)
  • Rasool, OmidTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland (author)
  • Halla-Aho, ViiviDepartment of Computer Science, Aalto University, Espoo, Finland (author)
  • Konki, MikkoTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (author)
  • Kattelus, RoosaTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland (author)
  • Mykkänen, JuhaResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland (author)
  • Nurmio, MirjaResearch Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland (author)
  • Vähä-Mäkilä, MariResearch Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland (author)
  • Kallionpää, HennaTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (author)
  • Lietzén, NiinaTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (author)
  • Ghimire, Bishwa R.Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland (author)
  • Laiho, AstaTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland (author)
  • Hyöty, HeikkiDepartment of Virology, Faculty of Medicine and Biosciences, University of Tampere, Tampere, Finland (author)
  • Elo, Laura L.Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland; Institute of Biomedicine, University of Turku, Turku, Finland (author)
  • Ilonen, JormaImmunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland (author)
  • Knip, MikaelPediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Center for Child Health Research, Tampere University Hospital, Tampere, Finland (author)
  • Lund, Riikka J.Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (author)
  • Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland(Swepub:oru)moc (author)
  • Veijola, RiittaDepartment of Pediatrics, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland (author)
  • Lähdesmäki, HarriDepartment of Computer Science, Aalto University, Espoo, Finland (author)
  • Toppari, JormaCentre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland; Department of Pediatrics, Turku University Hospital, Turku, Finland (author)
  • Lahesmaa, RiittaTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland; Institute of Biomedicine, University of Turku, Turku, Finland (author)
  • Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland; Turku Doctoral Programme of Molecular Medicine, University of Turku, Turku, Finland; Department of Computer Science, Aalto University, Espoo, FinlandTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland (creator_code:org_t)

Related titles

  • In:Diabetologia: Springer65:9, s. 1534-15400012-186X1432-0428

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