Integration of a droplet-based microfluidic system and silicon nanoribbon FET sensor

• We present a novel microfluidic system that integrates droplet microfluidics with a silicon nanoribbon field-effect transistor (SiNR FET), and utilize this integrated system to sense differences in pH. The device allows for selective droplet transfer to a continuous water phase, actuated by dielectrophoresis, and subsequent detection of the pH level in the retrieved droplets by SiNR FETs on an electrical sensor chip. The integrated microfluidic system demonstrates a label-free detection method for droplet microfluidics, presenting an alternative to optical fluorescence detection. In this work, we were able to differentiate between droplet trains of one pH-unit difference. The pH-based detection method in our integrated system has the potential to be utilized in the detection of biochemical reactions that induce a pH-shift in the droplets.

Subject headings

NATURVETENSKAP  -- Data- och informationsvetenskap (hsv//swe)

NATURAL SCIENCES  -- Computer and Information Sciences (hsv//eng)

TEKNIK OCH TEKNOLOGIER  -- Nanoteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Nano-technology (hsv//eng)

Keyword

Droplet microfluidics

NanoFET

PH measurement

Silicon nanoribbon

Drops

Electrophoresis

Field effect transistors

Fluidic devices

Integrated control

Nanoribbons

Silicon

Biochemical reactions

Droplet-based microfluidics

Integrated microfluidic systems

Label-free detection method

PH measurements

Microfluidics

Informations- och kommunikationsteknik

Publication and Content Type

ref (subject category)

art (subject category)