Interactions between model cell membranes and the neuroactive drug propofol

• phospholipid, NR data reveal that propofol is located exclusively in the head group region, which is rationalized in the context of previous studies. The results imply a non-homogeneous distribution of propofol in the plane of real cell membranes, which is an inference that requires urgent testing and may help to explain why such low concentration of the drug are required to induce general anaesthesia.

Ämnesord

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Nyckelord

Langmuir trough

Model membrane

Neutron reflectometry

Phospholipid monolayers

Propofol

Small amphiphilic drug

Surface pressure isotherm

Vibrational sum frequency spectroscopy

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)