Magnetic properties of nanoparticles as a function of their spatial distribution on liposomes and cells

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Fortes Brollo, Maria EugeniaCSIC Institute of Material Science of Madrid, Spain (författare)

Magnetic properties of nanoparticles as a function of their spatial distribution on liposomes and cells

Artikel/kapitelEngelska2018

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2018
Royal Society of Chemistry (RSC),2018
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:ri-33992
https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-33992URI
https://doi.org/10.1039/c8cp03016bDOI

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Språk:engelska
Sammanfattning på:engelska

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Anmärkningar

The aggregation processes of magnetic nanoparticles in biosystems are analysed by comparing the magnetic properties of three systems with different spatial distributions of the nanoparticles. The first one is iron oxide nanoparticles (NPs) of 14 nm synthesized by coprecipitation with two coatings, (3-aminopropyl)trimethoxysilane (APS) and dimercaptosuccinic acid (DMSA). The second one is liposomes with encapsulated nanoparticles, which have different configurations depending on the NP coating (NPs attached to the liposome surface or encapsulated in its aqueous volume). The last system consists of two cell lines (Pan02 and Jurkat) incubated with the NPs. Dynamic magnetic behaviour (AC) was analysed in liquid samples, maintaining their colloidal properties, while quasi-static (DC) magnetic measurements were performed on lyophilised samples. AC measurements provide a direct method for determining the effect of the environment on the magnetization relaxation of nanoparticles. Thus, the imaginary (χ'') component shifts to lower frequencies as the aggregation state increases from free nanoparticles to those attached or embedded into liposomes in cell culture media and more pronounced when internalized by the cells. DC magnetization curves show no degradation of the NPs after interaction with biosystems in the analysed timescale. However, the blocking temperature is shifted to higher temperatures for the nanoparticles in contact with the cells, regardless of the location, the incubation time, the cell line and the nanoparticle coating, supporting AC susceptibility data. These results indicate that the simple fact of being in contact with the cells makes the nanoparticles aggregate in a non-controlled way, which is not the same kind of aggregation caused by the contact with the cell medium nor inside liposomes.

Ämnesord och genrebeteckningar

NATURVETENSKAP Data- och informationsvetenskap hsv//swe
NATURAL SCIENCES Computer and Information Sciences hsv//eng

Biuppslag (personer, institutioner, konferenser, titlar ...)

Hernández Flores, PatriciaCSIC Centro Nacional de Biotecnología, Spain (författare)
Gutiérrez, LucíaINA Instituto Universitario de Nanociencia de Aragón, Spain (författare)
Johansson, ChristerRISE,Acreo(Swepub:ri)christer.johansson@ri.se (författare)
Barber, Domingo FranciscoCSIC Centro Nacional de Biotecnología, Spain (författare)
Morales, María Del PuertoCSIC Institute of Material Science of Madrid, Spain (författare)
CSIC Institute of Material Science of Madrid, SpainCSIC Centro Nacional de Biotecnología, Spain (creator_code:org_t)

Sammanhörande titlar

Ingår i:Physical Chemistry, Chemical Physics - PCCP: Royal Society of Chemistry (RSC)20:26, s. 17829-178381463-90761463-9084

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Physical Chemistry, Chemical Physics - PCCP (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Fortes Brollo, M ...; Hernández Flores ...; Gutiérrez, Lucía; Johansson, Chris ...; Barber, Domingo ...; Morales, María D ...

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NATURVETENSKAP: NATURVETENSKAP; och Data och informa ...

Artiklar i publikationen: Physical Chemist ...

Av lärosätet: RISE

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