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Antibiotic-Free Cat...
Antibiotic-Free Cationic Dendritic Hydrogels as Surgical-Site-Infection-Inhibiting Coatings
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- Andrén, Oliver C. J. (author)
- KTH,Ytbehandlingsteknik
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- Ingverud, Tobias, 1989- (author)
- KTH,Ytbehandlingsteknik
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- Hult, Daniel, 1986- (author)
- KTH,Ytbehandlingsteknik
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- Håkansson, Joakim (author)
- RISE,Kemi och material
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- Bogestål, Yalda (author)
- RISE,Kemi och material
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- Caous, Josefin S (author)
- RISE,Kemi och material,Metodik för produktframtagning
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- Blom, Kristina (author)
- Medibiome AB, Sweden
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- Zhang, Yuning (author)
- KTH,Fiber- och polymerteknologi
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- Andersson, Therese (author)
- RISE,Kemi och material
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- Pedersen, Emma (author)
- RISE,Kemi och material
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- Björn, Camilla (author)
- RISE,Kemi och material
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- Löwenhielm, Peter (author)
- RISE,Kemi och material
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- Malkoch, Michael, 1974- (author)
- KTH,Ytbehandlingsteknik
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(creator_code:org_t)
- 2019-02-08
- 2019
- English.
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In: Advanced Healthcare Materials. - : Wiley. - 2192-2640 .- 2192-2659.
- Related links:
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https://ri.diva-port... (primary) (Raw object)
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https://onlinelibrar...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- A non-toxic hydrolytically fast-degradable antibacterial hydrogel is herein presented to preemptively treat surgical site infections during the first crucial 24 h period without relying on conventional antibiotics. The approach capitalizes on a two-component system that form antibacterial hydrogels within 1 min and consist of i) an amine functional linear-dendritic hybrid based on linear poly(ethylene glycol) and dendritic 2,2-bis(hydroxymethyl)propionic acid, and ii) a di-N-hydroxysuccinimide functional poly(ethylene glycol) cross-linker. Broad spectrum antibacterial effect is achieved by multivalent representation of catatonically charged β-alanine on the dendritic periphery of the linear dendritic component. The hydrogels can be applied readily in an in vivo setting using a two-component syringe delivery system and the mechanical properties can accurately be tuned in the range equivalent to fat tissue and cartilage (G' = 0.5-8 kPa). The antibacterial effect is demonstrated both in vitro toward a range of relevant bacterial strains and in an in vivo mouse model of surgical site infection.
Subject headings
- NATURVETENSKAP -- Kemi -- Polymerkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Polymer Chemistry (hsv//eng)
Keyword
- antibacterial
- dendrimer
- hydrogels
- surgical-site infection
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Andrén, Oliver C ...
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Ingverud, Tobias ...
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Hult, Daniel, 19 ...
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Håkansson, Joaki ...
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Bogestål, Yalda
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Caous, Josefin S
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Blom, Kristina
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Zhang, Yuning
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Andersson, There ...
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Pedersen, Emma
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Björn, Camilla
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Löwenhielm, Pete ...
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Malkoch, Michael ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Polymer Chemistr ...
- Articles in the publication
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Advanced Healthc ...
- By the university
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RISE
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Royal Institute of Technology