Exposure to nicotine during periadolescence or early adulthood alters aversive and physiological effects induced by ethanol

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Riordan S) > Exposure to nicotin...

Rinker, Jennifer A.American University, Washington, DC, USA (författare)

Exposure to nicotine during periadolescence or early adulthood alters aversive and physiological effects induced by ethanol

Artikel/kapitelEngelska2011

Förlag, utgivningsår, omfång ...

Elsevier,2011
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:liu-101836
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-101836URI
https://doi.org/10.1016/j.pbb.2011.03.009DOI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

The majority of smokers begin their habit during adolescence, which often precedes experimentation with alcohol. Interestingly, very little preclinical work has been done examining how exposure to nicotine during periadolescence impacts the affective properties of alcohol in adulthood. Understanding how periadolescent nicotine exposure influences the aversive effects of alcohol might help to explain why it becomes more acceptable to this preexposed population. Thus, Experiment 1 exposed male Sprague Dawley rats to either saline or nicotine (0.4mg/kg, IP) from postnatal days 34 to 43 (periadolescence) and then examined changes in the aversive effects of alcohol (0, 0.56, 1.0 and 1.8g/kg, IP) in adulthood using the conditioned taste aversion (CTA) design. Changes in blood alcohol concentration (BAC) as well as alcohol-induced hypothermia and locomotor suppression were also assessed. To determine if changes seen were specific to nicotine exposure during periadolescence, the procedures were replicated in adults (Experiment 2). Preexposure to nicotine during periadolescence attenuated the acquisition of the alcohol-induced CTAs (at 1.0g/kg) and the hypothermic effects of alcohol (1.0g/kg). Adult nicotine preexposure produced similar attenuation in alcohol's aversive (at 1.8g/kg) and hypothermic (1.8g/kg) effects. Neither adolescent nor adult nicotine preexposure altered BACs or alcohol-induced locomotor suppression. These results suggest that nicotine may alter the aversive and physiological effects of alcohol, regardless of the age at which exposure occurs, possibly increasing its overall reinforcing value and making it more likely to be consumed.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Periadolescence; Preexposure; Nicotine; Conditioned taste aversion; Alcohol; Rats

Biuppslag (personer, institutioner, konferenser, titlar ...)

Hutchison, Mary AnneAmerican University, Washington, DC, USA (författare)
Chen, Scott A.National Institute on Drug Abuse, NIH, Bethesda, MD, USA (författare)
Thorsell, AnnikaNational Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA(Swepub:liu)annth96 (författare)
Heilig, MarkusNational Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA(Swepub:liu)marhe41 (författare)
Riley, Anthony L.American University, Washington, DC, USA (författare)
American University, Washington, DC, USANational Institute on Drug Abuse, NIH, Bethesda, MD, USA (creator_code:org_t)

Sammanhörande titlar

Ingår i:Pharmacology, Biochemistry and Behavior: Elsevier99:1, s. 7-160091-30571873-5177

Internetlänk

Hitta via bibliotek

Pharmacology, Biochemistry and Behavior (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Rinker, Jennifer ...; Hutchison, Mary ...; Chen, Scott A.; Thorsell, Annika; Heilig, Markus; Riley, Anthony L ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Neurovetenskaper

Artiklar i publikationen: Pharmacology, Bi ...

Av lärosätet: Linköpings universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se