Effects of lung tissue characterization in radiotherapy of breast cancer under deep inspiration breath hold when using Monte Carlo dosimetry

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Andersson, PatrikGothenburg University,Göteborgs universitet,RISE,University of Gothenburg, Sweden,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology (författare)

Effects of lung tissue characterization in radiotherapy of breast cancer under deep inspiration breath hold when using Monte Carlo dosimetry

Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

Associazione Italiana di Fisica Medica,2021
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Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:ri-56926
https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-56926URI
https://doi.org/10.1016/j.ejmp.2021.09.009DOI
https://gup.ub.gu.se/publication/310618URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

Funding details: Västra Götalandsregionen; Funding details: Strålsäkerhetsmyndigheten, SSM; Funding text 1: Financial support of King Gustav the V Jubilee Clinic Foundation, The Swedish Radiation Safety Authority and The Healthcare Committee, Region Västra Götaland are greatly acknowledged.
Purpose: To investigate the sensitivity of Monte Carlo (MC) calculated lung dose distributions to lung tissue characterization in external beam radiotherapy of breast cancer under Deep Inspiration Breath Hold (DIBH). Methods: EGSnrc based MC software was employed. Mean lung densities for one hundred patients were analysed. CT number frequency and clinical dose distributions were calculated for 15 patients with mean lung density below 0.14 g/cm3. Lung volume with a pre-defined CT numbers was also considered. Lung tissue was characterized by applying different CT calibrations in the low-density region and air-lung tissue thresholds. Dose impact was estimated by Dose Volume Histogram (DVH) parameters. Results: Mean lung densities below 0.14 g/cm3 were found in 10% of the patients. CT numbers below −960 HU dominated the CT frequency distributions with a high rate of CT numbers at −990 HU. Mass density conversion approach influenced the DVH shape. V4Gy and V8Gy varied by 7% and 5% for the selected patients and by 9% and 3.5% for the pre-defined lung volume. V16Gy and V20Gy, were within 2.5%. Regions above 20 Gy were affected. Variations in air- lung tissue differentiation resulted in DVH parameters within 1%. Threshold at −990 HU was confirmed by the CT number frequency distributions. Conclusions: Lung dose distributions were more sensitive to variations in the CT calibration curve below lung (inhale) density than to air-lung tissue differentiation. Low dose regions were mostly affected. The dosimetry effects were found to be potentially important to 10% of the patients treated under DIBH.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
Absorbed dose
Breast cancer radiotherapy
DIBH
Lung tissue characterization
Monte Carlo simulations
Article
breast cancer
breath holding
cancer radiotherapy
computer assisted tomography
deep inspiration breath hold
dose volume histogram
dosimetry
external beam radiotherapy
human
inspiratory capacity
lung parenchyma
lung volume
major clinical study
patient selection
radiation dose distribution
respiratory airflow
tissue characterization
Absorbed dose
Breast cancer radiotherapy
DIBH
Lung tissue characterization
Monte Carlo simulations

Biuppslag (personer, institutioner, konferenser, titlar ...)

Pettersson, NiclasSahlgrenska University Hospital, Sweden (författare)
Lindberg, AndreasSahlgrenska University Hospital, Sweden (författare)
Swanpalmer, John,1958Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för medicinsk strålningsvetenskap,Institute of Clinical Sciences, Department of Medical Radiation Sciences(Swepub:gu)xswajo (författare)
Chakarova, RoumianaGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för medicinsk strålningsvetenskap,Institute of Clinical Sciences, Department of Medical Radiation Sciences(Swepub:gu)xchakr (författare)
RISEUniversity of Gothenburg, Sweden (creator_code:org_t)

Sammanhörande titlar

Ingår i:Physica medica (Testo stampato): Associazione Italiana di Fisica Medica90, s. 83-901120-17971724-191X

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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