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Structure formation...
Structure formation and coarsening kinetics of phase-separated spin-coated ethylcellulose/hydroxypropylcellulose films
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- Carmona, Pierre, 1995 (författare)
- RISE,Jordbruk och livsmedel,Chalmers University of Technology, Sweden,Chalmers tekniska högskola,RISE Research Institutes of Sweden
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- Röding, Magnus (författare)
- Gothenburg University,Göteborgs universitet,RISE,Jordbruk och livsmedel,Chalmers University of Technology, Sweden; Gothenburg University, Sweden,RISE Research Institutes of Sweden,Chalmers tekniska högskola,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences
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- Särkkä, Aila, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers University of Technology, Sweden; Gothenburg University, Sweden
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- von Corswant, Christian (författare)
- AstraZeneca, Sweden,AstraZeneca AB
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- Olsson, Eva, 1960 (författare)
- Chalmers University of Technology, Sweden,Chalmers tekniska högskola
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- Loren, Niklas (författare)
- RISE,Jordbruk och livsmedel,Chalmers University of Technology, Sweden,RISE Research Institutes of Sweden,Chalmers tekniska högskola
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(creator_code:org_t)
- 2022
- 2022
- Engelska.
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Ingår i: Soft Matter. - : Royal Society of Chemistry. - 1744-683X .- 1744-6848. ; 18:16, s. 3206-3217
- Relaterad länk:
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Porous phase-separated ethylcellulose/hydroxypropylcellulose (EC/HPC) films are used to control drug transport from pharmaceutical pellets. The drug transport rate is determined by the structure of the porous films that are formed as water-soluble HPC leaches out. However, a detailed understanding of the evolution of the phase-separated structure in the films is lacking. In this work, we have investigated EC/HPC films produced by spin-coating, mimicking the industrial fluidized bed spraying. The aim was to investigate film structure evolution and coarsening kinetics during solvent evaporation. The structure evolution was characterized using confocal laser scanning microscopy and image analysis. The effect of the EC:HPC ratio (15 to 85 wt% HPC) on the structure evolution was determined. Bicontinuous structures were found for 30 to 40 wt% HPC. The growth of the characteristic length scale followed a power law, L(t) ∼ t(n), with n ∼ 1 for bicontinuous structures, and n ∼ 0.45-0.75 for discontinuous structures. The characteristic length scale after kinetic trapping ranged between 3.0 and 6.0 μm for bicontinuous and between 0.6 and 1.6 μm for discontinuous structures. Two main coarsening mechanisms could be identified: interfacial tension-driven hydrodynamic growth for bicontinuous structures and diffusion-driven coalescence for discontinuous structures. The 2D in-plane interface curvature analysis showed that the mean curvature decreased as a function of time for bicontinuous structures, confirming that interfacial tension is driving the growth. The findings of this work provide a good understanding of the mechanisms responsible for morphology development and open for further tailoring of thin EC/HPC film structures for controlled drug release. © 2022 The Royal Society of Chemistry
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
- NATURVETENSKAP -- Kemi -- Oorganisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Inorganic Chemistry (hsv//eng)
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
- NATURVETENSKAP -- Matematik (hsv//swe)
- NATURAL SCIENCES -- Mathematics (hsv//eng)
Nyckelord
- Coarsening
- Controlled drug delivery
- Fluidized beds
- Kinetics
- Ostwald ripening
- Bicontinuous structures
- Characteristic length
- Coarsening kinetics
- Ethylcellulose
- Film structure
- Formation kinetics
- Hydroxypro-pylcellulose
- Length scale
- Structure evolution
- Structure formations
- Separation
- cellulose
- hydroxypropylcellulose
- solvent
- water
- chemistry
- porosity
- Solvents
- to-cluster transition
- decomposition
- mixture
- confinement
- evaporation
- morphology
- dynamics
- gelatin
- growth
- Chemistry
- Materials Science
- Physics
- Polymer Science
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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