Structure formation and coarsening kinetics of phase-separated spin-coated ethylcellulose/hydroxypropylcellulose films

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Carmona, Pierre,1995RISE,Jordbruk och livsmedel,Chalmers University of Technology, Sweden,Chalmers tekniska högskola,RISE Research Institutes of Sweden (författare)

Structure formation and coarsening kinetics of phase-separated spin-coated ethylcellulose/hydroxypropylcellulose films

Artikel/kapitelEngelska2022

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2022
Royal Society of Chemistry,2022
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:ri-59252
https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-59252URI
https://doi.org/10.1039/d2sm00113fDOI
https://research.chalmers.se/publication/530114URI
https://gup.ub.gu.se/publication/315755URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype

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Funding details: 2019-01295; Funding details: Stiftelsen för Strategisk Forskning, SSF, FID16-0013; Funding details: Vetenskapsrådet, VR, 2018-03986; Funding text 1: The Swedish Foundation for Strategic Research (SSF grant FID16-0013), the Swedish Research Council (VR grant 2018-03986), and the Swedish Research Council for Sustainable Development (grant 2019-01295) are gratefully acknowledged for the funding. AstraZeneca is acknowledged for the financial support and materials. Philip Townsend, RISE/Chalmers, is acknowledged for his contribution to the 2D-curvature estimation.
Porous phase-separated ethylcellulose/hydroxypropylcellulose (EC/HPC) films are used to control drug transport from pharmaceutical pellets. The drug transport rate is determined by the structure of the porous films that are formed as water-soluble HPC leaches out. However, a detailed understanding of the evolution of the phase-separated structure in the films is lacking. In this work, we have investigated EC/HPC films produced by spin-coating, mimicking the industrial fluidized bed spraying. The aim was to investigate film structure evolution and coarsening kinetics during solvent evaporation. The structure evolution was characterized using confocal laser scanning microscopy and image analysis. The effect of the EC:HPC ratio (15 to 85 wt% HPC) on the structure evolution was determined. Bicontinuous structures were found for 30 to 40 wt% HPC. The growth of the characteristic length scale followed a power law, L(t) ∼ t(n), with n ∼ 1 for bicontinuous structures, and n ∼ 0.45-0.75 for discontinuous structures. The characteristic length scale after kinetic trapping ranged between 3.0 and 6.0 μm for bicontinuous and between 0.6 and 1.6 μm for discontinuous structures. Two main coarsening mechanisms could be identified: interfacial tension-driven hydrodynamic growth for bicontinuous structures and diffusion-driven coalescence for discontinuous structures. The 2D in-plane interface curvature analysis showed that the mean curvature decreased as a function of time for bicontinuous structures, confirming that interfacial tension is driving the growth. The findings of this work provide a good understanding of the mechanisms responsible for morphology development and open for further tailoring of thin EC/HPC film structures for controlled drug release. © 2022 The Royal Society of Chemistry

Ämnesord och genrebeteckningar

TEKNIK OCH TEKNOLOGIER Medicinteknik Medicinsk material- och protesteknik hsv//swe
ENGINEERING AND TECHNOLOGY Medical Engineering Medical Materials hsv//eng
NATURVETENSKAP Kemi Oorganisk kemi hsv//swe
NATURAL SCIENCES Chemical Sciences Inorganic Chemistry hsv//eng
NATURVETENSKAP Kemi Fysikalisk kemi hsv//swe
NATURAL SCIENCES Chemical Sciences Physical Chemistry hsv//eng
NATURVETENSKAP Kemi Materialkemi hsv//swe
NATURAL SCIENCES Chemical Sciences Materials Chemistry hsv//eng
NATURVETENSKAP Matematik hsv//swe
NATURAL SCIENCES Mathematics hsv//eng
Coarsening
Controlled drug delivery
Fluidized beds
Kinetics
Ostwald ripening
Bicontinuous structures
Characteristic length
Coarsening kinetics
Ethylcellulose
Film structure
Formation kinetics
Hydroxypro-pylcellulose
Length scale
Structure evolution
Structure formations
Separation
cellulose
hydroxypropylcellulose
solvent
water
chemistry
porosity
Solvents
to-cluster transition
decomposition
mixture
confinement
evaporation
morphology
dynamics
gelatin
growth
Chemistry
Materials Science
Physics
Polymer Science

Biuppslag (personer, institutioner, konferenser, titlar ...)

Röding, MagnusGothenburg University,Göteborgs universitet,RISE,Jordbruk och livsmedel,Chalmers University of Technology, Sweden; Gothenburg University, Sweden,RISE Research Institutes of Sweden,Chalmers tekniska högskola,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences(Swepub:cth)roding (författare)
Särkkä, Aila,1962Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers University of Technology, Sweden; Gothenburg University, Sweden(Swepub:gu)xsarai (författare)
von Corswant, ChristianAstraZeneca, Sweden,AstraZeneca AB (författare)
Olsson, Eva,1960Chalmers University of Technology, Sweden,Chalmers tekniska högskola(Swepub:cth)f10eva (författare)
Loren, NiklasRISE,Jordbruk och livsmedel,Chalmers University of Technology, Sweden,RISE Research Institutes of Sweden,Chalmers tekniska högskola(Swepub:cth)lorenn (författare)
RISEJordbruk och livsmedel (creator_code:org_t)

Sammanhörande titlar

Ingår i:Soft Matter: Royal Society of Chemistry18:16, s. 3206-32171744-683X1744-6848

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Av författaren/redakt...: Carmona, Pierre, ...; Röding, Magnus; Särkkä, Aila, 19 ...; von Corswant, Ch ...; Olsson, Eva, 196 ...; Loren, Niklas

Om ämnet

TEKNIK OCH TEKNOLOGIER: TEKNIK OCH TEKNO ...; och Medicinteknik; och Medicinsk materi ...

NATURVETENSKAP: NATURVETENSKAP; och Kemi; och Oorganisk kemi

NATURVETENSKAP: NATURVETENSKAP; och Kemi; och Fysikalisk kemi

NATURVETENSKAP: NATURVETENSKAP; och Kemi; och Materialkemi

NATURVETENSKAP: NATURVETENSKAP; och Matematik

Artiklar i publikationen: Soft Matter

Av lärosätet: RISE; Chalmers tekniska högskola; Göteborgs universitet

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