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  • Kjellin, PerPromimic AB, Sweden (author)

Biomechanical and histomorphometric evaluation of skin integration on titanium and PEEK implants with different surface treatments

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-09-30
  • Springer,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:ri-61212
  • https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-61212URI
  • https://doi.org/10.1007/s10856-022-06687-yDOI
  • https://gup.ub.gu.se/publication/322760URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding details: 214487; Funding details: Sahlgrenska Akademin; Funding text 1: Toponova AB, Halmstad, Sweden, is acknowledged for the interferometry measurements. Petra Hammarström Johansson at the Institute of Odontology, Sahlgrenska Academy, Gothenburg, is acknowledged for the histology processing. The study was partly financed by Region Västra Götaland FoU-card advanced (Dnr 214487); Funding text 2: Toponova AB, Halmstad, Sweden, is acknowledged for the interferometry measurements. Petra Hammarström Johansson at the Institute of Odontology, Sahlgrenska Academy, Gothenburg, is acknowledged for the histology processing. The study was partly financed by Region Västra Götaland FoU-card advanced (Dnr 214487)
  • Percutaneous implants are frequently affected by bacterial growth at the skin-implant interface. Integration between implant and surrounding skin is important to prevent bacteria from spreading to the underlying tissue. The standard method to evaluate skin-implant integration is by histomorphometry on samples which have been placed in tissue grown in vivo or ex vivo. In this study, a biomechanical method was developed and evaluated. The integration of implants into porcine skin was studied in an ex vivo model, where pig skin samples were cultivated in a nutrient solution. Cylindrical shaped implants, consisting of polyether ether ketone (PEEK) and titanium (Ti) with different surface treatments, were implanted in the skin tissue and the skin was grown in nutrient solution for 2 weeks. The implants were then extracted from the implantation site and the mechanical force during extraction was measured as a quantitative assessment of skin-implant integration. Implants from each group were also processed for histomorphometry and the degree of epidermal downgrowth (ED) and tissue to implant contact (TIC) was measured. A higher mean pullout force was observed for the PEEK implants compared to the Ti implants. Applying nanosized hydroxyapatite (HA) on Ti and PEEK increased the pullout force compared to uncoated controls, 24% for machined and 70% for blasted Ti, and 51% for machined PEEK. Treatment of Ti and PEEK with nanosized zirconium phosphate (ZrP) did not increase the pullout force. The histomorphometry analysis showed correlation between ED and pullout force, where the pullout force was inversely proportional to ED. For TIC, no significant differences were observed between the groups of same material (i.e. Ti, Ti+HA, Ti+ZrP, and PEEK, PEEK + HA, PEEK + ZrP), but it was significantly higher for PEEK compared to Ti. Scanning electron microscopy analysis was done on samples before and after the pullout tests, showing that the ZrP coating was unaffected by the 2 week ex vivo implantation and pullout procedure, no dissolution or detachment of the coating was observed. For the HA coating, a loss of coating was seen on approximately 5% of the total surface area of the implant. [Figure not available: see fulltext.] © 2022, The Author(s).

Subject headings and genre

  • MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Annan medicinsk bioteknologi hsv//swe
  • MEDICAL AND HEALTH SCIENCES Medical Biotechnology Other Medical Biotechnology hsv//eng
  • MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
  • MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng
  • Bacteria
  • Biocompatibility
  • Biomechanics
  • Coatings
  • Ethers
  • Integration
  • Ketones
  • Mammals
  • Nutrients
  • Scanning electron microscopy
  • Tissue
  • Titanium carbide
  • Bacterial growth
  • Ex-vivo
  • Histomorphometry
  • Implant interfaces
  • In-vivo
  • Nutrient solution
  • Pullout force
  • Skin implants
  • Titania
  • Zirconium phosphate
  • Hydroxyapatite
  • nanohydroxyapatite
  • nanomaterial
  • polyetheretherketone
  • titanium
  • unclassified drug
  • benzophenone derivative
  • ether derivative
  • ketone
  • macrogol
  • polymer
  • animal experiment
  • animal tissue
  • Article
  • bone tissue
  • coating (procedure)
  • controlled study
  • dissolution
  • ex vivo study
  • force
  • implantation
  • morphometry
  • nonhuman
  • quantitative analysis
  • surface area
  • surface property
  • Yorkshire pig
  • animal
  • osseointegration
  • pig
  • tooth implant
  • Animals
  • Benzophenones
  • Dental Implants
  • Durapatite
  • Polyethylene Glycols
  • Polymers
  • Surface Properties
  • Swine
  • Bacteria
  • Biocompatibility
  • Biomechanics
  • Coatings
  • Ethers
  • Integration
  • Ketones
  • Mammals
  • Nutrients
  • Scanning electron microscopy
  • Tissue
  • Titanium carbide
  • Bacterial growth
  • Ex-vivo
  • Histomorphometry
  • Implant interfaces
  • In-vivo
  • Nutrient solution
  • Pullout force
  • Skin implants
  • Titania
  • Zirconium phosphate
  • Hydroxyapatite
  • nanohydroxyapatite
  • nanomaterial
  • polyetheretherketone
  • titanium
  • unclassified drug
  • benzophenone derivative
  • ether derivative
  • ketone
  • macrogol
  • polymer
  • animal experiment
  • animal tissue
  • Article
  • bone tissue
  • coating (procedure)
  • controlled study
  • dissolution
  • ex vivo study
  • force
  • implantation
  • morphometry
  • nonhuman
  • quantitative analysis
  • surface area
  • surface property
  • Yorkshire pig
  • animal
  • osseointegration
  • pig
  • tooth implant
  • Animals
  • Benzophenones
  • Dental Implants
  • Durapatite
  • Polyethylene Glycols
  • Polymers
  • Surface Properties
  • Swine

Added entries (persons, corporate bodies, meetings, titles ...)

  • Danielsson, KarinPromimic AB, Sweden (author)
  • Håkansson, JoakimGothenburg University,Göteborgs universitet,RISE,Metodik för produktframtagning,University of Gothenburg, Sweden,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xhakjo (author)
  • Agrenius, KarinRISE,Kemi och Tillämpad mekanik(Swepub:ri)karinag@ri.se (author)
  • Andersson, ThereseRISE,Metodik för produktframtagning(Swepub:ri)theresean@ri.se (author)
  • Stenlund, PatrikRISE,Metodik för produktframtagning(Swepub:ri)PatrikSt@ri.se (author)
  • Promimic AB, SwedenMetodik för produktframtagning (creator_code:org_t)

Related titles

  • In:Journal of materials science. Materials in medicine: Springer33:100957-45301573-4838

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