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Sensitive methods for assessment of lung health in welders and controls
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- Petersson Sjögren, Madeleine (författare)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,MERGE: ModElling the Regional and Global Earth system,Centrum för miljö- och klimatvetenskap (CEC),Naturvetenskapliga fakulteten,LTH profilområde: Aerosoler,LTH profilområden,LU profilområde: Ljus och material,Lunds universitets profilområden,Other operations, LTH,Faculty of Engineering, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,Centre for Environmental and Climate Science (CEC),Faculty of Science,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH,LU Profile Area: Light and Materials,Lund University Profile areas,Lund University, Sweden
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- Kåredal, Monica (författare)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,LTH profilområde: Aerosoler,LTH profilområden,LU profilområde: Ljus och material,Lunds universitets profilområden,Other operations, LTH,Faculty of Engineering, LTH,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Genetic Occupational and Environmental Medicine,Lund University Research Groups,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH,LU Profile Area: Light and Materials,Lund University Profile areas,Lund University, Sweden; Region Skåne, Sweden
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- Broberg, Karin (författare)
- Karolinska Institutet,Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,LTH profilområde: Aerosoler,LTH profilområden,Lunds Tekniska Högskola,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Genetic Occupational and Environmental Medicine,Lund University Research Groups,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH,Lund University, Sweden; Karolinska Institute, Sweden
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- W.B. Saunders Ltd, 2023
- 2023
- Engelska.
- Ingår i: Respiratory Medicine. - : W.B. Saunders Ltd. - 0954-6111 .- 1532-3064. ; 212
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Background: Welders are exposed to gas and particle emissions that can cause severe lung disease, such as chronic obstructive pulmonary disease (COPD), a leading cause of mortality and morbidity worldwide. It is difficult to detect COPD early and therefore mitigating measures may be delayed. The aim of this study was to investigate lung health in welders and evaluate new sensitive methods with potential to assess early onset pulmonary changes in occupational settings. Methods: This study assessed the lung health and symptoms in active welders (n = 28) and controls (n = 17). Lung measurements were performed with standard spirometry and new methods: airspace dimension assessment (AiDA), oscillometry, blood serum biomarkers (club cell secretory protein 16, surfactant protein D, matrix metalloproteinases, fibroblast, hepatocyte growth factor, interleukins), and one urine biomarker (desmosine). Results: According to spirometry measurements, all participants had normal lung function. However, prevalence of cough was significantly higher among welders compared with controls and lung changes were found in welders with the novel methods. Welders had significantly higher respiratory system resistance assessed with oscillometry, serum levels of metalloproteinases 9 and hepatocyte growth factor, compared with controls. Airspace dimensions were on average higher among welders compared with controls, but the difference was not significant. The number of welding years correlated with decreased respiratory system reactance and increased serum levels of matrix metalloproteinases 9, interleukin 6, and hepatocyte growth factor. Airspace dimension assessment indices were correlated with increasing levels of inflammatory markers and matrix metalloproteinases. Conclusions: This study indicated the potential to use new and more sensitive methods for identification of changes in lungs when standard spirometry failed to do so. © 2023 The Authors
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Airspace dimension assessment with nanoparticles AiDA
- Chronic obstructive pulmonary disease
- Occupational exposure
- Oscillometry
- Respiratory diagnostics
- Respiratory disease biomarkers
- Welders
- cytokine
- desmosine
- gelatinase B
- interleukin 6
- matrix metalloproteinase
- scatter factor
- surfactant protein D
- adult
- Article
- controlled study
- fibroblast
- health
- human
- human cell
- lung
- lung development
- lung function
- major clinical study
- male
- middle aged
- protein blood level
- spirometry
- welding
- Airspace dimension assessment with nanoparticles AiDA
- Chronic obstructive pulmonary disease
- Occupational exposure
- Oscillometry
- Respiratory diagnostics
- Respiratory disease biomarkers
- Welders
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Petersson Sjögre ...
- Kåredal, Monica
- Broberg, Karin
- Assarsson, Eva
- Thuresson, Sara
- Dierschke, Katri ...
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- Hedmer, Maria
- Rissler, Jenny
- Wollmer, Per
- Löndahl, Jakob
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