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WFRF:(Larsson Callerfelt Anna Karin)
 

Sökning: WFRF:(Larsson Callerfelt Anna Karin) > Uncovering the cyto...

  • Al-Rekabi, ZeinabNPL National Physical Laboratory, UK (författare)

Uncovering the cytotoxic effects of air pollution with multi-modal imaging of in vitro respiratory models

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Royal Society Publishing,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:ri-64853
  • https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-64853URI
  • https://doi.org/10.1098/rsos.221426DOI
  • https://lup.lub.lu.se/record/8ed54c8b-dd2d-42a1-ae11-611c4791772bURI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • The authors acknowledge funding from the EMPIR programme (project AeroTox, 18HLT02), which is co-financed by the Participating States and the European Union's Horizon 2020 research and innovation programme.
  • Annually, an estimated seven million deaths are linked to exposure to airborne pollutants. Despite extensive epidemiological evidence supporting clear associations between poor air quality and a range of short- and long-term health effects, there are considerable gaps in our understanding of the specific mechanisms by which pollutant exposure induces adverse biological responses at the cellular and tissue levels. The development of more complex, predictive, in vitro respiratory models, including two- and three-dimensional cell cultures, spheroids, organoids and tissue cultures, along with more realistic aerosol exposure systems, offers new opportunities to investigate the cytotoxic effects of airborne particulates under controlled laboratory conditions. Parallel advances in high-resolution microscopy have resulted in a range of in vitro imaging tools capable of visualizing and analysing biological systems across unprecedented scales of length, time and complexity. This article considers state-of-the-art in vitro respiratory models and aerosol exposure systems and how they can be interrogated using high-resolution microscopy techniques to investigate cell-pollutant interactions, from the uptake and trafficking of particles to structural and functional modification of subcellular organelles and cells. These data can provide a mechanistic basis from which to advance our understanding of the health effects of airborne particulate pollution and develop improved mitigation measures. 

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Dondi, CamillaNPL National Physical Laboratory, UK (författare)
  • Faruqui, NilofarNPL National Physical Laboratory, UK (författare)
  • Siddiqui, Nazia S.University College London, UK; Kingston Hospital NHS Foundation Trust, UK (författare)
  • Elowsson, LindaLund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups(Swepub:lu)biot-lel (författare)
  • Rissler, JennyLund University,Lunds universitet,RISE,Material- och ytdesign,Lund university, Sweden,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,LTH profilområde: Aerosoler,LTH profilområden,LTH profilområde: Nanovetenskap och halvledarteknologi,LU profilområde: Ljus och material,Lunds universitets profilområden,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH,LTH Profile Area: Nanoscience and Semiconductor Technology,Faculty of Engineering, LTH,LU Profile Area: Light and Materials,Lund University Profile areas,Research Institutes of Sweden (RISE)(Swepub:lu)nucl-jri (författare)
  • Kåredal, MonicaLund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,LTH profilområde: Aerosoler,LTH profilområden,LTH profilområde: Nanovetenskap och halvledarteknologi,LU profilområde: Ljus och material,Lunds universitets profilområden,Other operations, LTH,Faculty of Engineering, LTH,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Genetic Occupational and Environmental Medicine,Lund University Research Groups,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH,LTH Profile Area: Nanoscience and Semiconductor Technology,Faculty of Engineering, LTH,LU Profile Area: Light and Materials,Lund University Profile areas(Swepub:lu)ymed-mkr (författare)
  • Mudway, IanImperial College, UK; National institute of health protection, UK; Asthma UK, UK,Imperial College London (författare)
  • Larsson-Callerfelt, Anna KarinLund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,LTH profilområde: Aerosoler,LTH profilområden,Lunds Tekniska Högskola,Lung Biology,Lund University Research Groups,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH(Swepub:lu)med-ail (författare)
  • Shaw, MichaelNPL National Physical Laboratory, UK; University College London, UK (författare)
  • NPL National Physical Laboratory, UKUniversity College London, UK; Kingston Hospital NHS Foundation Trust, UK (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Royal Society Open Science: Royal Society Publishing10:42054-5703

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