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  • Svensson, Sara,1981Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials (author)

Osseointegration of titanium with an antimicrobial nanostructured noble metal coating

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • Elsevier BV,2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:ri-6533
  • https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-6533URI
  • https://doi.org/10.1016/j.nano.2013.04.009DOI
  • https://gup.ub.gu.se/publication/177588URI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Nanometer scale surface features on implants and prostheses can potentially be used to enhance osseointegration and may also add further functionalities, such as infection resistance, to the implant. In this study, a nanostructured noble metal coating consisting of palladium, gold and silver, never previously used in bone applications, was applied to machined titanium screws to evaluate osseointegration after 6 and 12. weeks in rabbit tibiae and femurs. Infection resistance was confirmed by in vitro adhesion test. A qualitatively and quantitatively similar in vivo bone response was observed for the coated and uncoated control screws, using histology, histomorphometry and electron microscopy. The bone-implant interface analysis revealed an extensive bone formation and direct bone-implant contact. These results demonstrate that the nanostructured noble metal coating with antimicrobial properties promotes osseointegration and may therefore be used to add extra implant functionality in the form of increased resistance to infection without the use of antibiotics. From the Clinical Editor: The authors of this paper demonstrate that nanostructured noble metal coating of implants and prostheses used in orthopedic procedures promotes osseointegration and may be used to add extra implant functionality in the form of increased resistance to infection without the use of antibiotics.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Suska, Felicia,1974Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials(Swepub:gu)xsusfe (author)
  • Emanuelsson, Lena,1961Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials(Swepub:gu)xemale (author)
  • Palmquist, Anders,1977Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials(Swepub:gu)xpaand (author)
  • Norlindh, Birgitta,1958Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials(Swepub:gu)xnorlb (author)
  • Trobos, Margarita,1980Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials(Swepub:gu)xtroma (author)
  • Bäckros, HelenBIOMATCELL, Sweden; Bactiguard AB, Sweden (author)
  • Persson, LindaBIOMATCELL, Sweden; Bactiguard AB, Sweden (author)
  • Rydja, Gunilla I.BIOMATCELL, Sweden; Bactiguard AB, Sweden (author)
  • Ohrlander, MattiasBIOMATCELL, Sweden; Bactiguard AB, Sweden (author)
  • Lyvén, BennyRISE,SP – Sveriges Tekniska Forskningsinstitut,BIOMATCELL, Sweden(Swepub:ri)BennyL@ri.se (author)
  • Lausmaa, JukkaRISE,SP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf)(Swepub:gu)xlauju (author)
  • Thomsen, Peter,1953Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials(Swepub:gu)xthope (author)
  • Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap (creator_code:org_t)

Related titles

  • In:Nanomedicine: Nanotechnology, Biology, and Medicine: Elsevier BV9:7, s. 1048-10561549-96341549-9642

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